1. Vitamin D Related
    Epigenetics
    Cell Cycle/DNA Damage
  2. VD/VDR
    HDAC
  3. Triciferol

Triciferol 

Cat. No.: HY-131961
Handling Instructions

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities.

For research use only. We do not sell to patients.

Triciferol Chemical Structure

Triciferol Chemical Structure

CAS No. : 957214-00-5

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Description

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].

In Vitro

Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells[1].
Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB231 breast cancer cells
Concentration: 0-10000 nM
Incubation Time: 0-72 hours
Result: Growth inhibition was statistically significantly different from that of 1,25D at concentrations of 1 nM or above.
Molecular Weight

429.59

Formula

C₂₆H₃₉NO₄

CAS No.

957214-00-5

SMILES

C[[email protected]@H]([[email protected]]1CC[[email protected]@]2([H])/C(CCC[[email protected]]12C)=C/C=C3C[[email protected]@H](O)C[[email protected]](O)C/3)/C=C(C)/C=C/C(NO)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TriciferolVD/VDRHDACVitamin DVitamin D receptorHistone deacetylasestubulinhyperacetylationhistoneacetylationantiproliferativeligandInhibitorinhibitorinhibit

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Triciferol
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HY-131961
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