2. Anti-infection
  3. Parasite
  4. Dianellin

Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria.

For research use only. We do not sell to patients.

Dianellin

Dianellin Chemical Structure

CAS No. : 58829-72-4

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Dianellin Related Antibodies

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Description

Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria[1].

In Vitro

Dianellin weakly binds to Plasmodium falciparum plasmepsin II and does not bind to Plasmodium falciparum pfLDH[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dianellin Related Antibodies
In Vivo

Dianellin (25-100 mg/kg; i.g.; daily; 4 days) exhibits dose-dependent in vivo anti-malarial activity against Plasmodium berghei in Swiss albino mice, with an ED50 of 92.31 mg/kg and up to 53.77% parasitaemia suppression at the highest tested dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino (5-6 weeks old, 20-25 g, male or female, intraperitoneally inoculated with Plasmodium berghei ANKA strain-infected erythrocytes)[1]
Dosage: 25, 50, 100 mg/kg
Administration: p.o.; daily; 4 days
Result: Achieved 29.83% parasitaemia suppression and a mean survival time of 7.6 days at 25 mg/kg/day.
Achieved 44.04% parasitaemia suppression and a mean survival time of 8.2 days at 50 mg/kg/day.
Achieved 53.77% parasitaemia suppression and a mean survival time of 8.2 days at 100 mg/kg/day.
Demonstrated statistically significant suppression compared to negative control (p < 0.001).
Had a median effective dose (ED50) of 92.31 mg/kg.
Molecular Weight

524.51

Formula

C25H32O12
CAS No.
SMILES

OC1=C(C(C)=O)C(C)=CC2=CC=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C)O4)O3)O)=C21
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dianellin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dianellin58829-72-4Parasitel-lactate dehydrogenase*Kniphofa foliosa*Swiss albino mice*Plasmodium falciparum*plasmepsin IImalariarhizomespfLDHnaphthalene glycoside*Plasmodium berghei*Inhibitorinhibitorinhibit

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