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Cat. No.: HY-N19628

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Dianellin

Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 58829-72-4
Formule: C₂₅H₃₂O₁₂
Masse moléculaire:524.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Dianellin Chemical Structure

CAS No.: 58829-72-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Parasite :

In Vitro

Dianellin weakly binds to Plasmodium falciparum plasmepsin II and does not bind to Plasmodium falciparum pfLDH^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dianellin (25-100 mg/kg; i.g.; daily; 4 days) exhibits dose-dependent in vivo anti-malarial activity against Plasmodium berghei in Swiss albino mice, with an ED₅₀ of 92.31 mg/kg and up to 53.77% parasitaemia suppression at the highest tested dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Swiss albino (5-6 weeks old, 20-25 g, male or female, intraperitoneally inoculated with Plasmodium berghei ANKA strain-infected erythrocytes)^[1]
Dosage:

25, 50, 100 mg/kg
Administration:

p.o.; daily; 4 days
Result:

Achieved 29.83% parasitaemia suppression and a mean survival time of 7.6 days at 25 mg/kg/day.
Achieved 44.04% parasitaemia suppression and a mean survival time of 8.2 days at 50 mg/kg/day.
Achieved 53.77% parasitaemia suppression and a mean survival time of 8.2 days at 100 mg/kg/day.
Demonstrated statistically significant suppression compared to negative control (p < 0.001).
Had a median effective dose (ED₅₀) of 92.31 mg/kg.

Chemical Information

CAS No. 58829-72-4
Masse moléculaire 524.51
Formule C₂₅H₃₂O₁₂
SMILES

OC1=C(C(C)=O)C(C)=CC2=CC=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C)O4)O3)O)=C21
Structure Classification
- Phenols
- Monophenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Alebachew Y, et al. In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents. Malar J. 2021;20(1):3. Published 2021 Jan 1. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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