1. Anti-infection
  2. Bacterial
  3. LpxC-IN-5

LpxC-IN-5 

Cat. No.: HY-131907
Handling Instructions

LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively.

For research use only. We do not sell to patients.

LpxC-IN-5 Chemical Structure

LpxC-IN-5 Chemical Structure

CAS No. : 2253951-38-9

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Description

LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively[1].

In Vitro

LpxC is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of Lipid A, an essential component of the cell envelope of Gram-negative bacteria[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

412.44

Formula

C₂₁H₂₄N₄O₅

CAS No.

2253951-38-9

SMILES

C[[email protected]@H](C1=NC=CN1CC2=NOC(C#CC3=CC=C(C=C3)OCC(CO)(CO)N)=C2)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LpxC-IN-5BacterialLpxCzincmetalloenzymeLipidAantibacterialactivityInhibitorinhibitorinhibit

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