2253951-38-9
2253951-38-9
Chemical Structure
LpxC-IN-5
- No. CAS: 2253951-38-9
- Formula:C21H24N4O5
- Molecular Weight:412.44
IUPAC Name: (S)-2-amino-2-((4-((3-((2-(1-hydroxyethyl)-1H-imidazol-1-yl)methyl)isoxazol-5-yl)ethynyl)phenoxy)methyl)propane-1,3-diol
InChIKey: DKGUWMFQYQOPSO-HNNXBMFYSA-N
SMILES: C[C@@H](C1=NC=CN1CC2=NOC(C#CC3=CC=C(C=C3)OCC(CO)(CO)N)=C2)O
Biological Activity: LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively[1].
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LpxC-IN-5 | LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively. | |||||||||||||||||||||
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