1. Epigenetics
  2. Histone Acetyltransferase

YF-2 

Cat. No.: HY-16531 Purity: 99.36%
Handling Instructions

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.

For research use only. We do not sell to patients.

YF-2 Chemical Structure

YF-2 Chemical Structure

CAS No. : 1311423-89-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of YF-2:

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

IC50 & Target[1]

CBP

2.75 μM (EC50)

PCAF

29.04 μM (EC50)

GCN5

49.31 μM (EC50)

In Vitro

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

In Vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (290.12 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3210 mL 11.6050 mL 23.2099 mL
5 mM 0.4642 mL 2.3210 mL 4.6420 mL
10 mM 0.2321 mL 1.1605 mL 2.3210 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.83 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

430.85

Formula

C₂₀H₂₂ClF₃N₂O₃

CAS No.

1311423-89-8

SMILES

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
YF-2
Cat. No.:
HY-16531
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YF-2

Cat. No.: HY-16531