1. Epigenetics
  2. Histone Acetyltransferase

YF-2 hydrochloride 

Cat. No.: HY-16531A
Handling Instructions

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.

For research use only. We do not sell to patients.

YF-2 hydrochloride Chemical Structure

YF-2 hydrochloride Chemical Structure

CAS No. : 1312005-62-1

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

IC50 & Target[1]

CBP

2.75 μM (EC50)

PCAF

29.04 μM (EC50)

GCN5

49.31 μM (EC50)

In Vitro

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

In Vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1399 mL 10.6995 mL 21.3991 mL
5 mM 0.4280 mL 2.1399 mL 4.2798 mL
10 mM 0.2140 mL 1.0700 mL 2.1399 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

467.31

Formula

C₂₀H₂₃Cl₂F₃N₂O₃

CAS No.

1312005-62-1

SMILES

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
YF-2 hydrochloride
Cat. No.:
HY-16531A
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YF-2 hydrochloride

Cat. No.: HY-16531A