1. Epigenetics
  2. Histone Acetyltransferase
  3. YF-2 hydrochloride

YF-2 hydrochloride 

Cat. No.: HY-16531A
Handling Instructions

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease.

For research use only. We do not sell to patients.

YF-2 hydrochloride Chemical Structure

YF-2 hydrochloride Chemical Structure

CAS No. : 1312005-62-1

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5 mg USD 350 Get quote
10 mg USD 550 Get quote
50 mg USD 1650 Get quote
100 mg USD 2650 Get quote

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Description

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

IC50 & Target[1]

CBP

2.75 μM (EC50)

PCAF

29.04 μM (EC50)

GCN5

49.31 μM (EC50)

In Vitro

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

In Vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

467.31

Formula

C₂₀H₂₃Cl₂F₃N₂O₃

CAS No.

1312005-62-1

SMILES

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
YF-2 hydrochloride
Cat. No.:
HY-16531A
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YF-2 hydrochloride

Cat. No.: HY-16531A