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Cat. No.: HY-121511

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EML631

EML631 is a SPIN1 inhibitor with a K_d of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2101206-36-2
Formula: C₄₁H₆₀N₆O₃
Molecular Weight:684.97

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Please store the product under the recommended conditions in the Certificate of Analysis.

EML631 Chemical Structure

CAS No.: 2101206-36-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All Epigenetic Reader Domain Isoforms :

All Wnt Isoforms :

In Vitro

EML631 (15-30 mM), like SPIN-DOC, blocks the H3K4me3 reading ability of SPIN1 in T778 cells and exerts identical effects on Wnt signaling pathway activity^[1].
EML631 specifically binds to the Tudor domain of SPIN1, with a K_d value of 3-7 μM as measured by ITC^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2101206-36-2
Molecular Weight 684.97
Formula C₄₁H₆₀N₆O₃
SMILES

O=C(C1=CC=C(C(=O)N2CCC(CC2)CCN3CCCC3)C(=C1)NC4=CC=C(OCN5CCCC5)C=C4)N6CCC(CC6)CCN7CCCC7
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bae N, et al. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017;292(51):20808-20817. [Content Brief]

[2]. Uguen M, et al. Tudor-Containing Methyl-Lysine and Methyl-Arginine Reader Proteins: Disease Implications and Chemical Tool Development. ACS Chem Biol. 2025;20(1):33-47. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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EML631

All Epigenetic Reader Domain Isoforms

All Wnt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EML631 Related Classifications

HY-121511 Related Classifications