2. Epigenetics Stem Cell/Wnt
  3. Epigenetic Reader Domain Wnt
  4. EML631

EML631 is a SPIN1 inhibitor with a Kd of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research.

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EML631

EML631 Chemical Structure

CAS No. : 2101206-36-2

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EML631 Related Antibodies

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Description

EML631 is a SPIN1 inhibitor with a Kd of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research[1][2].

In Vitro

EML631 (15-30 mM), like SPIN-DOC, blocks the H3K4me3 reading ability of SPIN1 in T778 cells and exerts identical effects on Wnt signaling pathway activity[1].
EML631 specifically binds to the Tudor domain of SPIN1, with a Kd value of 3-7 μM as measured by ITC[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EML631 Related Antibodies
Molecular Weight

684.97

Formula

C41H60N6O3
CAS No.
SMILES

O=C(C1=CC=C(C(=O)N2CCC(CC2)CCN3CCCC3)C(=C1)NC4=CC=C(OCN5CCCC5)C=C4)N6CCC(CC6)CCN7CCCC7
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Room temperature in continental US; may vary elsewhere.
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References
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EML631 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EML6312101206-36-2EML 631EML-631Epigenetic Reader DomainWntSpindlin1ovarian cancernonsmall cell lung cancersHEK293T cell lysatesWnt signaling pathwayH3K4me3 histone marksecond Tudor domainbreast cancerSPIN1liposarcomaInhibitorinhibitorinhibit

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