Cat. No.: HY-126640

Phomoxanthone A

Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively.

For research use only. We do not sell to patients.

CAS No.: 359844-69-2
Formula: C₃₈H₃₈O₁₆
Molecular Weight:750.70

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Phomoxanthone A Chemical Structure

CAS No.: 359844-69-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Classifications
Bioz

Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.58 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
A2780	IC₅₀	0.75 μM Compound: PXA	Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
A2780	IC₅₀	1.01 μM Compound: PXA	Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
A2780	IC₅₀	1.18 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31443950]
A2780	IC₅₀	1.44 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	0.86 μM Compound: PXA	Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
A2780cisR	IC₅₀	1.18 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	1.25 μM Compound: PXA	Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
A2780cisR	IC₅₀	1.37 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	1.88 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31443950]
BC1 cell line	IC₅₀	0.51 μg/mL Compound: 1	Cytotoxicity against human BC1 cells by SRB assay Cytotoxicity against human BC1 cells by SRB assay	[PMID: 11520217]
CAL-27	IC₅₀	5.25 μM Compound: PXA	Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
HCT-116	IC₅₀	1.82 μM Compound: PXA	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	2.04 μM Compound: PXA	Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	2.75 μM Compound: PXA	Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.12 μM Compound: PXA	Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.23 μM Compound: PXA	Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	3.34 μM Compound: PXA	Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.75 μM Compound: PXA	Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
K562	IC₅₀	1.86 μM Compound: PXA	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
KB	IC₅₀	0.99 μg/mL Compound: 1	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 11520217]
KYSE-510	IC₅₀	0.76 μM Compound: PXA	Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
KYSE-510	IC₅₀	0.79 μM Compound: PXA	Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
MDA-MB-231	IC₅₀	3.7 μM Compound: PXA	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
MDA-MB-231	IC₅₀	4.37 μM Compound: PXA	Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
Vero	IC₅₀	1.4 μg/mL Compound: 1	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 11520217]

Chemical Information

CAS No. 359844-69-2
Molecular Weight 750.70
Formula C₃₈H₃₈O₁₆
SMILES

O=C1C2=C(O[C@@]3(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C31)C(C4=CC=C(O)C5=C4O[C@@]6(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C6C5=O)=CC=C2O
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Microorganisms
Endophytic Fungus Phomopsis Species
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Isaka M, et al., Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. J Nat Prod. 2001 Aug;64(8):1015-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Phomoxanthone A

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Phomoxanthone A Related Classifications

HY-126640 Related Classifications