359844-69-2
Chemical Structure
Phomoxanthone A
- CAS No.: 359844-69-2
- Formula:C38H38O16
- Molecular Weight:750.70
IUPAC Name: (5S,5'S,6S,6'S,10aS,10'aS)-10a,10'a-bis(acetoxymethyl)-1,1',8,8'-tetrahydroxy-6,6'-dimethyl-9,9'-dioxo-5,5',7,7',9,9',10a,10'a-octahydro-6H,6'H-[4,4'-bixanthene]-5,5'-diyl diacetate
InChIKey: OHHXJWHRQGZQJM-CMDKCIDSSA-N
SMILES: O=C1C2=C(O[C@@]3(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C31)C(C4=CC=C(O)C5=C4O[C@@]6(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C6C5=O)=CC=C2O
Biological Activity: Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC50 is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC50 is 0.99, 0.51 and 1.4 µg/mL, respectively[1].
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Phomoxanthone A | Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC50 is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC50 is 0.99, 0.51 and 1.4 µg/mL, respectively. | |||||||||||||||||||||
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