hSET1/SET1 Antibody (YA6854)
(Synonyms: Histone-lysine N-methyltransferase SETD1A antibody; hSET1A antibody; KMT2F antibody; Lysine N methyltransferase 2F antibody; Lysine N-methyltransferase 2F antibody; SET domain containing 1A antibody; SET domain containing protein 1A antibody; SET domain-containing protein 1A antibody; SET1 antibody; Set1 Ash2 histone methyltransferase complex subunit SET1 antibody; Histone-lysine N-methyltransferase SETD1A antibody; hSET1A antibody; KMT2F antibody; Lysine N methyltransferase 2F antibody; Lysine N-methyltransferase 2F antibody; SET domain containing 1A antibody; SET domain containing protein 1A antibody; SET domain-containing protein 1A antibody; SET1 antibody; Set1 Ash2 histone methyltransferase complex subunit SET1 antibody; Set1/Ash2 histone methyltransferase complex subunit SET1 antibody; SET1A antibody; SET1A_HUMAN antibody; SETD1A antibody; )hSET1/SET1 Antibody (YA6854) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hSET1/SET1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, FC
-
Reactivity :
Human
-
Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
FC
FC: Flow Cytometry
|
|---|---|---|
| Dilution Ratio | 1:1000 | 1:500-1:1000 |
Product Details
hSET1/SET1 Antibody (YA6854) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hSET1/SET1.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman Predicted Reactivity: Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
-
Observed Molecular WeightObserved band size: 300 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 186 kDa
Recombinant protein within C terminal human SET1A.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
hSET1/SET1 is a Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place. Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis. Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation. Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated. Binds RNAs involved in RNA processing and the DNA damage response[1][2][3][4][5][6].
-
Subcellular Localization
Nucleus speckle,Chromosome,Cytoplasm
-
Isoforms & Post-Translational Modification
O15047: 1707 amino acids, molecular weight 186034 Da.
-
Subunit
Component of the SET1A/COMPASS complex composed of the catalytic subunit SETD1A, WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 homotrimer (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538, PubMed:22266653, PubMed:22665483, PubMed:23508102)
-
SwissProt ID
-
Synonyms
Histone-lysine N-methyltransferase SETD1A antibody; hSET1A antibody; KMT2F antibody; Lysine N methyltransferase 2F antibody; Lysine N-methyltransferase 2F antibody; SET domain containing 1A antibody; SET domain containing protein 1A antibody; SET domain-containing protein 1A antibody; SET1 antibody; Set1 Ash2 histone methyltransferase complex subunit SET1 antibody; Histone-lysine N-methyltransferase SETD1A antibody; hSET1A antibody; KMT2F antibody; Lysine N methyltransferase 2F antibody; Lysine N-methyltransferase 2F antibody; SET domain containing 1A antibody; SET domain containing protein 1A antibody; SET domain-containing protein 1A antibody; SET1 antibody; Set1 Ash2 histone methyltransferase complex subunit SET1 antibody; Set1/Ash2 histone methyltransferase complex subunit SET1 antibody; SET1A antibody; SET1A_HUMAN antibody; SETD1A antibody;
Documentation
Powered by Bioz
