ZLD10A
ZLD10A is a highly potent and selective EZH2 inhibitor with the activity of inhibiting H3K27 methylation. ZLD10A can inhibit wild-type and mutant EZH2 with nanomolar potency and has more than 1000-fold selectivity for the other 10 histone methyltransferases. ZLD10A inhibited cell proliferation of DLBCL cell lines in a concentration- and time-dependent manner, showing a potential antiproliferative effect. ZLD10A can be used in the study of EZH2 mutant lymphomas.
For research use only. We do not sell to patients.
- CAS No.: 1782064-91-8
- Formula: C37H48N4O4
- Molecular Weight:612.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Pfeiffer | IC50 |
19.5 μM
Compound: 18c; ZLD10A
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Antiproliferative activity against human Pfeiffer cells
Antiproliferative activity against human Pfeiffer cells
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[PMID: 35531606] |
| SU-DHL-6 | IC50 |
20 μM
Compound: 18c; ZLD10A
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Antiproliferative activity against human SU-DHL-6 cells
Antiproliferative activity against human SU-DHL-6 cells
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[PMID: 35531606] |
Chemical Information
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CAS No. 1782064-91-8
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Molecular Weight 612.80
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Formula C37H48N4O4
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SMILES
O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(CCCC6)C6=C(C)NC5=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZLD10A Related Classifications
HY-117540 Related Classifications
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