HDAC degrader-2
HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 μM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma.
For research use only. We do not sell to patients.
- Formula: C32H35ClN4O5
- Molecular Weight:591.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 2.55 μM (DC50) |
HDAC2 |
HDAC-degrader 2 (Compound SZ-2) (24 h) exerted potent antiproliferative effects against MM.1S (IC50 = 3.28 μM) and MCF-7 (IC50 = 3.46 μM) cells[1].
HDAC-degrader 2 (5 μM, 48 h) significantly induces apoptosis in MM.1S cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM.1S cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Significantly increased the percentages of early and late apoptotic cells.
Chemical Information
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Molecular Weight 591.10
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Formula C32H35ClN4O5
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SMILES
O=C(NCCCCCCC(NO)=O)C1=CC=C(C2CC(C3=CC=CC(OCC4=CC=CC=C4)=C3)=NN2C(CCl)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC degrader-2 Related Classifications
HY-178161 Related Classifications
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