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  2. Parasite
  3. CWHM-1552

CWHM-1552 

Cat. No.: HY-128354
Handling Instructions

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.

For research use only. We do not sell to patients.

CWHM-1552 Chemical Structure

CWHM-1552 Chemical Structure

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Description

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively[1].

IC50 & Target

IC50: 51 nM (3D7 strain) and 53 nM (Dd2 strain)[1]

In Vivo

CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day[1].
CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice[1].
CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively[1].

Animal Model: P. chabaudi ASS infected Mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: Orally; daily for 4 days
Result: Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
Animal Model: Male KM mice[1]
Dosage: 2 mg/kg
Administration: I.v. administration; daily
Result: Had respectable half-lives (2.7 h) and low clearance in mice.
Molecular Weight

387.47

Formula

C₂₂H₂₇F₂N₃O

SMILES

CN(C)C1=CC=C(CC(N[[email protected]@H]2CNC[[email protected]]2C3=CC=C(C(F)(C)F)C=C3)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CWHM-1552
Cat. No.:
HY-128354
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