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Art. -Nr.: HY-128354

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CWHM-1552

Name: CWHM-1552
Brand: MedChemExpress
SKU: HY-128354
Price: 315.00 USD
Availability: InStock
Rating: 5 (1 reviews)

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC₅₀s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2368253-58-9
Formel: C₂₂H₂₇F₂N₃O
Molecular Weight:387.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

CWHM-1552 Chemical Structure

CAS. Nr.: 2368253-58-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC₅₀s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively^[1].

IC₅₀ & Target

IC50: 51 nM (3D7 strain) and 53 nM (Dd2 strain)^[1]

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In Vivo

CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day^[1].
CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice^[1].
CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED₉₀ of <10 mg/kg/day and ED₉₉ of 30 mg/kg/day, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

P. chabaudi ASS infected Mice^[1]
Dosage:

3, 10, 30 mg/kg
Administration:

Orally; daily for 4 days
Result:

Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.

Animal Model:

Male KM mice^[1]
Dosage:

2 mg/kg
Administration:

I.v. administration; daily
Result:

Had respectable half-lives (2.7 h) and low clearance in mice.

Chemical Information

CAS. Nr. 2368253-58-9
Molecular Weight 387.47
Formel C₂₂H₂₇F₂N₃O
SMILES

CN(C)C1=CC=C(CC(N[C@@H]2CNC[C@H]2C3=CC=C(C(F)(C)F)C=C3)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Meyers MJ, et al. 4-Aryl Pyrrolidines as Novel Orally Efficacious Antimalarial Agents. Part 2: 2-Aryl-N-(4-arylpyrrolidin-3-yl) acetamides. ACS Med Chem Lett. 2019 May, 10(6):966-971. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
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CWHM-1552

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vivo

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CWHM-1552 Related Classifications

HY-128354 Related Classifications

Bioz

Keywords

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