CWHM-1552
CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2368253-58-9
- Formula: C22H27F2N3O
- Molecular Weight:387.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 51 nM (3D7 strain) and 53 nM (Dd2 strain)[1]
CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice[1].
CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P. chabaudi ASS infected Mice[1]
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Dosage:3, 10, 30 mg/kg
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Administration:Orally; daily for 4 days
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Result:Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
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Animal Model:Male KM mice[1]
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Dosage:2 mg/kg
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Administration:I.v. administration; daily
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Result:Had respectable half-lives (2.7 h) and low clearance in mice.
Chemical Information
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CAS No. 2368253-58-9
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Molecular Weight 387.47
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Formula C22H27F2N3O
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SMILES
CN(C)C1=CC=C(CC(N[C@@H]2CNC[C@H]2C3=CC=C(C(F)(C)F)C=C3)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CWHM-1552 Related Classifications
HY-128354 Related Classifications
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