HDAC/HSP90-IN-2
HDAC/HSP90-IN-2 (compound 26) is a potent dual inhibitor of HDAC (IC50 = 360 nM) and HSP90 (HSP90α IC50 = 77 nM). HDAC/HSP90-IN-2 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-2 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-2 can be used for cancer research, such as lung and colon cancer.
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- CAS. Nr.: 2244714-45-0
- Formel: C26H35N3O6
- Molecular Weight:485.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC 360 nM (IC50) |
HSP90α 77 nM (IC50) |
HSP70 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.44 μM
Compound: 26
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Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay
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[PMID: 31655430] |
Chemical Information
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CAS. Nr. 2244714-45-0
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Molecular Weight 485.57
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Formel C26H35N3O6
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SMILES
CC(C1=C(O)C=C(O)C(C(N(C)C2=CC=C(NC(CCCCCCCC(NO)=O)=O)C=C2)=O)=C1)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Mehndiratta S, et al. N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression. Eur J Med Chem. 2020 Jan 1;185:111725. doi: 10.1016/j.ejmech.2019.111725. Epub 2019 Sep 24. Erratum in: Eur J Med Chem. 2020 Aug 1;199:112406. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC/HSP90-IN-2 Related Classifications
HY-130274 Related Classifications
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