2244714-45-0
Chemical Structure
HDAC/HSP90-IN-2
- CAS No.: 2244714-45-0
- Formula:C26H35N3O6
- Molecular Weight:485.57
IUPAC Name: N1-(4-(2,4-dihydroxy-5-isopropylbenzamido)phenyl)-N9-hydroxynonanediamide
InChIKey: BPYXZYFZLYBSIO-UHFFFAOYSA-N
SMILES: CC(C1=C(O)C=C(O)C(C(N(C)C2=CC=C(NC(CCCCCCCC(NO)=O)=O)C=C2)=O)=C1)C
Biological Activity: HDAC/HSP90-IN-2 (compound 26) is a potent dual inhibitor of HDAC (IC50 = 360 nM) and HSP90 (HSP90α IC50 = 77 nM). HDAC/HSP90-IN-2 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-2 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-2 can be used for cancer research, such as lung and colon cancer[1].
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HDAC/HSP90-IN-2 | HDAC/HSP90-IN-2 (compound 26) is a potent dual inhibitor of HDAC (IC50 = 360 nM) and HSP90 (HSP90α IC50 = 77 nM). HDAC/HSP90-IN-2 induces HSP70 expression, downregulates HSP90 client proteins, and promotes acetylation of α-tubulin and histone H3 in cancer cells. HDAC/HSP90-IN-2 reduces PD-L1 expression in IFN-γ treated H1975 cells. HDAC/HSP90-IN-2 can be used for cancer research, such as lung and colon cancer. | |||||||||||||||||||||
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- [1]. Mehndiratta S, et al. N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression. Eur J Med Chem. 2020 Jan 1;185:111725. doi: 10.1016/j.ejmech.2019.111725. Epub 2019 Sep 24. Erratum in: Eur J Med Chem. 2020 Aug 1;199:112406. [Content Brief]
Keywords
