HDAC7 Antibody (YA3146)
(Synonyms: HDAC7; HDAC7A; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a)
Based on 1 Customer Validation
HDAC7 Antibody (YA3146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC7.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
HDAC7 Antibody (YA3146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HDAC7.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 124 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 103 kDa
Entrez Gene: 51564 Human ; 56233 Mouse ;
SwissProt: Q8WUI4 Human ; Q8C2B3 Mouse ; Q99P96 Rat
OMIM: 606542 Human
A synthesized peptide derived from human HDAC7 aa35-200.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HDAC7 (histone deacetylase 7) is a class IIa histone deacetylase that functions as a signal-responsive transcriptional coregulator linking extracellular stimuli to chromatin-dependent gene regulation and cell fate control[1][2]. HDAC7 undergoes regulated nucleo-cytoplasmic shuttling through phosphorylation-dependent mechanisms, allowing it to integrate signaling pathways with transcriptional programs that govern development, immunity, and vascular biology[1][3]. Mechanistically, HDAC7 participates in the control of endothelial growth, migration, angiogenesis, and vascular integrity, and VEGF-dependent signaling can promote HDAC7 phosphorylation and redistribution to regulate endothelial responses[3][4][5]. In disease-associated contexts, aberrant HDAC7 expression has been linked to tumor progression, metastasis, vascular microenvironment remodeling, and therapeutic resistance, supporting its relevance as a candidate biomarker and experimental target in cancer research[6]. Compared with related class IIa isoforms, including HDAC4, HDAC5, and HDAC9, HDAC7 is distinguished by its prominent role as a signaling hub that couples cellular localization dynamics with transcriptional regulation in endothelial and immune systems[1][2]. Furthermore, class IIa HDACs possess relatively low intrinsic deacetylase activity and frequently function through protein-protein interactions and corepressor complexes; HDAC7 has been reported to associate with HDAC3, highlighting a mechanistic distinction from catalytically active class I HDACs[7]. For experimental applications, HDAC-targeting compounds such as vorinostat affect HDAC7 among other HDAC family members, and ongoing efforts to improve isoform selectivity continue to inform the design of epigenetic and cancer-focused research strategies[6][8].
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Subcellular Localization
Nucleus; Cytoplasm
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Isoforms & Post-Translational Modification
Q8WUI4 has 10 isomers: Q8WUI4-1: 102927 Da (predicted); Q8WUI4-2: 51829 Da (predicted); Q8WUI4-3: 99093 Da (predicted); Q8WUI4-4: 99755 Da (predicted); Q8WUI4-5: 106740 Da (predicted); Q8WUI4-6: 105111 Da (predicted); Q8WUI4-7: 102906 Da (predicted); Q8WUI4-8: 108937 Da (predicted); Q8WUI4-9: 46041 Da (predicted); Q8WUI4-10: 66187 Da (predicted).
May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181 -
Subunit
Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3 (PubMed:11466315). Interacts with KAT5 and EDNRA (PubMed:11262386, PubMed:12551922).
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SwissProt ID
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Synonyms
HDAC7; HDAC7A; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a
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Research Field
Epigenetics and Nuclear Signaling
Documentation
[1]. Atochin DN, et al. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest. 2007 Jul;117(7):1961-7. [Content Brief]
[2]. Margariti A, et al. Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin. Circ Res. 2010 Apr 16;106(7):1202-11. [Content Brief]
[3]. Yin X, et al. Multiple red blood cell flows through microvascular bifurcations: cell free layer, cell trajectory, and hematocrit separation. Microvasc Res. 2013 Sep;89:47-56. [Content Brief]
[4]. Liu C, et al. HDAC7: a promising target in cancer. Front Oncol. 2024 Feb 28;14:1327933. [Content Brief]
[5]. Rabezanahary H, et al. Live virus neutralizing antibodies against pre and post Omicron strains in food and retail workers in Québec, Canada. Heliyon. 2024 May 21;10(10):e31026. [Content Brief]
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