1. Epigenetics
  2. Histone Methyltransferase
  3. AS-85

AS-85 

Cat. No.: HY-141430
Handling Instructions

AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM.

For research use only. We do not sell to patients.

AS-85 Chemical Structure

AS-85 Chemical Structure

CAS No. : 2323623-80-7

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Description

AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM[1].

In Vitro

AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

579.66

Formula

C₂₆H₂₈F₃N₅O₃S₂

CAS No.
SMILES

O=C(C1CNC1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AS-85AS85AS 85Histone MethyltransferasehistonemethyltransferaseMLLfusionleukemiatranslocationsInhibitorinhibitorinhibit

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