1. Epigenetics
  2. Histone Methyltransferase
  3. AS-85

AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM.

For research use only. We do not sell to patients.

AS-85 Chemical Structure

AS-85 Chemical Structure

CAS No. : 2323623-80-7

Size Price Stock Quantity
1 mg USD 170 In-stock
5 mg USD 500 In-stock
10 mg USD 850 In-stock
25 mg USD 1800 In-stock
50 mg USD 2880 In-stock
100 mg USD 4600 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM[1].

In Vitro

AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring different MLL1 translocations, with GI50 values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

579.66

Formula

C26H28F3N5O3S2

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1CNC1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (172.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7251 mL 8.6257 mL 17.2515 mL
5 mM 0.3450 mL 1.7251 mL 3.4503 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.96%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7251 mL 8.6257 mL 17.2515 mL 43.1287 mL
5 mM 0.3450 mL 1.7251 mL 3.4503 mL 8.6257 mL
10 mM 0.1725 mL 0.8626 mL 1.7251 mL 4.3129 mL
15 mM 0.1150 mL 0.5750 mL 1.1501 mL 2.8752 mL
20 mM 0.0863 mL 0.4313 mL 0.8626 mL 2.1564 mL
25 mM 0.0690 mL 0.3450 mL 0.6901 mL 1.7251 mL
30 mM 0.0575 mL 0.2875 mL 0.5750 mL 1.4376 mL
40 mM 0.0431 mL 0.2156 mL 0.4313 mL 1.0782 mL
50 mM 0.0345 mL 0.1725 mL 0.3450 mL 0.8626 mL
60 mM 0.0288 mL 0.1438 mL 0.2875 mL 0.7188 mL
80 mM 0.0216 mL 0.1078 mL 0.2156 mL 0.5391 mL
100 mM 0.0173 mL 0.0863 mL 0.1725 mL 0.4313 mL
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AS-85 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
AS-85
Cat. No.:
HY-141430
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