2323623-80-7
2323623-80-7
Chemical Structure
AS-85
- CAS. Nr.: 2323623-80-7
- Formula:C26H28F3N5O3S2
- Molecular Weight:579.66
IUPAC Name: N-((3-(3-carbamothioylphenyl)-1-(1-((trifluoromethyl)sulfonyl)piperidin-4-yl)-1H-indol-6-yl)methyl)azetidine-3-carboxamide
InChIKey: WDQKQCWRQIVDBA-UHFFFAOYSA-N
SMILES: O=C(C1CNC1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5
Biological Activity: AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 μM[1].
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AS-85 | 98.05% | AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 μM. | ||||||||||||||||||||
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References
Keywords
