1. Epigenetics
  2. Histone Methyltransferase
  3. MRK-740

MRK-740 

Cat. No.: HY-114209 Purity: >99.0%
Handling Instructions

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 µM).

For research use only. We do not sell to patients.

MRK-740 Chemical Structure

MRK-740 Chemical Structure

CAS No. : 2387510-80-5

Size Price Stock Quantity
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 385 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50 = 0.8 µM)[1].

IC50 & Target

IC50: 80 nM (PRDM9)[1]

In Vitro

After 24 h of treatment, MRK-740 (3 µM) does not affect HEK293T cell growth at the IC90, but some toxicity is observed at 10 µM. MRK-740 is an equipotent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 specifically and directly inhibits H3K4 methylation at endogenous PRDM9 target loci[1].

Molecular Weight

464.56

Formula

C₂₅H₃₂N₆O₃

CAS No.

2387510-80-5

SMILES

CC1=NC=CC(N(CC2)CCC32CN(C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)CCN3C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

MRK-740MRK740MRK 740Histone MethyltransferasePRDM9substrate-competitiveH3K4trimethylationInhibitorinhibitorinhibit

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Product Name:
MRK-740
Cat. No.:
HY-114209
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