1. Epigenetics
  2. Histone Demethylase
  3. PBIT

PBIT 

Cat. No.: HY-101451
Handling Instructions

PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC5 s of 6 and 4.9 μM, respectively.

For research use only. We do not sell to patients.

PBIT Chemical Structure

PBIT Chemical Structure

CAS No. : 2514-30-9

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Description

PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC5 s of 6 and 4.9 μM, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

241.31

Formula

C₁₄H₁₁NOS

CAS No.

2514-30-9

SMILES

O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3

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Room temperature in continental US; may vary elsewhere

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PBIT
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PBIT

Cat. No.: HY-101451