2514-30-9
2514-30-9
Chemical Structure
PBIT
- CAS No.: 2514-30-9
- Formula:C14H11NOS
- Molecular Weight:241.31
IUPAC Name: 2-(p-tolyl)benzo[d]isothiazol-3(2H)-one
InChIKey: KRXMYBAZKJBJAB-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=C(C)C=C2)SC3=C1C=CC=C3
Biological Activity: PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PBIT | 99.13% | PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively. | ||||||||||||||||||||
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Structural Analogs
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HY-128170Ebsulfur -
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HY-138802ML089 -
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HY-124044ML 086 -
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HY-124890Thr101 -
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HY-157145SARS-CoV-2-IN-69 -
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HY-112945MLS0315771 -
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HY-124696PU139 -
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HY-147288NSC 694621 -
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HY-147290NSC 694623 -
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