1. Epigenetics
  2. Histone Demethylase
  3. PFI-90

PFI-90 

Cat. No.: HY-139348
Handling Instructions

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

For research use only. We do not sell to patients.

PFI-90 Chemical Structure

PFI-90 Chemical Structure

CAS No. : 53995-62-3

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Description

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

IC50 & Target

IC50: 812 nM (RH4); 3200 nM (RH30); 1895 nM (OSA-CL); 1113 nM (TC-32)[1]

In Vitro

PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1].
PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: RH4 and SCMC cells
Concentration: 3 μΜ
Incubation Time: 24 hours
Result: Apoptosis increased in RH4 and SCMC cells.
Molecular Weight

214.22

Formula

C₁₁H₁₀N₄O

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PFI-90
Cat. No.:
HY-139348
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