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Cat. No.: HY-161419

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EZH2-IN-18

EZH2-IN-18 (compound 9e) is a potent inhibitor of enhancer of zeste homologue 2 (EZH2^WT) , with the IC₅₀ of 1.01 nM. EZH2-IN-18 shows inhibition in proliferation and induction in apoptosis in tumor cells.

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CAS No.: 2826234-37-9
Formule: C₂₄H₂₀BrN₃O₃
Masse moléculaire:478.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

EZH2-IN-18 Chemical Structure

CAS No.: 2826234-37-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.04 μM Compound: 9e	Antiproliferative activity against human A549 cells by MTT assay Antiproliferative activity against human A549 cells by MTT assay	[PMID: 38580135]
HeLa	IC₅₀	25.33 μM Compound: 9e	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 38580135]

Chemical Information

CAS No. 2826234-37-9
Masse moléculaire 478.34
Formule C₂₄H₂₀BrN₃O₃
SMILES

O=C1C(CNC(C2=CC(C3=CC=C(Br)C=C3)=CC(N4)=C2C=CC4=O)=O)=C(C)C=C(C)N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jin Cai, et al. Design, synthesis and activity evaluation of quinolinone derivatives as EZH2 inhibitors. Bioorg Med Chem Lett. 2024 Jun 1:105:129726. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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EZH2-IN-18

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EZH2-IN-18 Related Classifications

HY-161419 Related Classifications