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SIRT6 activator 3

SIRT6 activator 3 (Compound 24) is a SIRT6 activator with an EC₅₀ of 5 μM. SIRT6 activator 3 exhibits histone deacetylation activity. SIRT6 activator 3 can be used in cancer research.

For research use only. We do not sell to patients.

Formula: C₂₃H₂₁ClO₅
Molecular Weight:412.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIRT6 activator 3 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

SIRT6 activator 3 (Compound 24) is a SIRT6 activator with an EC₅₀ of 5 μM. SIRT6 activator 3 exhibits histone deacetylation activity. SIRT6 activator 3 can be used in cancer research^[1].

IC₅₀ & Target^[1]

SIRT6

5 μM (EC₅₀)

All Sirtuin Isoforms :

In Vitro

SIRT6 activator 3 is a SIRT6 activator with an EC₅₀ of 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 412.86
Formula C₂₃H₂₁ClO₅
SMILES

O=C1C=C(OC)C[C@@H](C)[C@@]21OC3=C(Cl)C(C4=CC=C(C)C=C4)=CC(OC)=C3C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zorko T, et al. Lead Optimization: Synthesis and Biological Evaluation of Griseofulvin Derivatives as Novel SIRT6 Activators. ACS Med Chem Lett. 2026;17(3):662-669. Published 2026 Mar 3. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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