MTA2 Antibody (YA3344)
(Synonyms: Mata1l1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; Mmta2; MTA1L1; p53 target protein in deacetylase complex; PID)
Based on 1 Customer Validation
MTA2 Antibody (YA3344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MTA2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 | 1:50-1:100 |
Product Details
MTA2 Antibody (YA3344) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MTA2.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 75 kDa
A synthesized peptide derived from human MTA2 aa600-668/668.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MTA2 may function as a transcriptional coregulator. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin[1][2].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Widely expressed -
Isoforms & Post-Translational Modification
O94776 has 2 isomers: O94776-1: 75023 Da (predicted); O94776-2: 55037 Da (predicted).
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Subunit
Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:28977666, PubMed:33283408).
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SwissProt ID
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Synonyms
Mata1l1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; Mmta2; MTA1L1; p53 target protein in deacetylase complex; PID
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Research Field
Epigenetics and Nuclear Signaling
Documentation
[1]. Le Guezennec X, et al. MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties. Mol Cell Biol. 2006 Feb;26(3):843-51. [Content Brief]
[2]. Hoffmeister H, et al. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. Nucleic Acids Res. 2017 Oct 13;45(18):10534-10554. [Content Brief]
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