LIN28 inhibitor LI71
Based on 1 publication(s) in Google Scholar
LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC50: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC50: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum.
For research use only. We do not sell to patients.
- Purity: 98.67%
- CAS No.: 1357248-83-9
- Formula: C21H21NO3
- Molecular Weight:335.40
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Epigenetics Compound Library
HY-L005
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Blood Cancer Compound Library
HY-L079
-
Antiparasitic Compound library
HY-L082
-
Anti-Hematopathy Compound Library
HY-L171
-
Epigenetics Compound Library Mini
HY-L005M
-
High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) LIN28 inhibitor LI71
MoreAll Parasite Isoforms
More
Biological Activity
IC50: 7 uM (LIN28)[1]
LIN28 inhibitor LI71 competitively blocks the interaction between LIN28 and let-7 precursor by directly binding to the cold shock domain (CSD) of LIN28 (IC50: 7 μM)[1].
LIN28 inhibitor LI71 (40 μM, 40 minutes) can effectively inhibit LIN28-mediated oligouridylation of let-7 precursor, thereby preventing the degradation of let-7 and restoring the level of mature let-7 (IC50: 27 μM)[1].
LIN28 inhibitor LI71 (100 μM) shows that it directly binds to CSD rather than zinc joint domain (ZKD) or let-7 RNA in saturation transfer difference (STD) spectroscopy experiments[1]
LIN28 inhibitor LI71 (50-100 μM) can effectively inhibit cell viability in HeLa cells expressing LIN28A and LIN28B without significant cytotoxicity[1].
LIN28 inhibitor LI71 (100 μM, 48 hours) significantly increases the expression level of mature let-7 in leukemia cells (K562) and embryonic stem cells (mESCs), thereby inhibiting cell viability[1].
LIN28 inhibitor LI71 inhibits the interaction of PfCoSP with DNA and α/β tubulin by competitively binding to PfCoSP[2].
LIN28 inhibitor LI71 (1.95-250 nM, 72 hours) has IC50s of 1.35 nM and 6.3 nM in 3D7 and RKL-9 strains of Plasmodium falciparum, respectively[2].
LIN28 inhibitor LI71 (10-500 nM, 30 minutes) affects the gametogenesis of Plasmodium falciparum and inhibits the deflagellation of male gametes in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1357248-83-9
-
Appearance Solid
-
Molecular Weight 335.40
-
Formula C21H21NO3
-
Color Yellow to green
-
SMILES
O=C(O)C1=CC=C([C@@H]2NC3=C(C=CC=C3OCC)[C@@]4([H])[C@]2([H])CC=C4)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (298.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
-
Handling Instructions (2659 KB)
References
[1]. Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 Jun 5;23(10):3091-3101. [Content Brief]
[2]. Behl A,et al. Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite. iScience. 2023 Apr 11;26(5):106637. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9815 mL | 14.9076 mL | 29.8151 mL | 74.5379 mL |
| 5 mM | 0.5963 mL | 2.9815 mL | 5.9630 mL | 14.9076 mL | |
| 10 mM | 0.2982 mL | 1.4908 mL | 2.9815 mL | 7.4538 mL | |
| 15 mM | 0.1988 mL | 0.9938 mL | 1.9877 mL | 4.9692 mL | |
| 20 mM | 0.1491 mL | 0.7454 mL | 1.4908 mL | 3.7269 mL | |
| 25 mM | 0.1193 mL | 0.5963 mL | 1.1926 mL | 2.9815 mL | |
| 30 mM | 0.0994 mL | 0.4969 mL | 0.9938 mL | 2.4846 mL | |
| 40 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8634 mL | |
| 50 mM | 0.0596 mL | 0.2982 mL | 0.5963 mL | 1.4908 mL | |
| 60 mM | 0.0497 mL | 0.2485 mL | 0.4969 mL | 1.2423 mL | |
| 80 mM | 0.0373 mL | 0.1863 mL | 0.3727 mL | 0.9317 mL | |
| 100 mM | 0.0298 mL | 0.1491 mL | 0.2982 mL | 0.7454 mL |
LIN28 inhibitor LI71 Related Classifications
HY-123905 Related Classifications
Powered by Bioz