1. Epigenetics
  2. Histone Methyltransferase
  3. Dot1L-IN-6

Dot1L-IN-6 

Cat. No.: HY-135129
Handling Instructions

Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM.

For research use only. We do not sell to patients.

Dot1L-IN-6 Chemical Structure

Dot1L-IN-6 Chemical Structure

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Description

Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM[1].

In Vitro

Dot1L-IN-6 (Compound 9) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=12 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=170 nM)[1].

In Vivo

Dot1L-IN-6 (Compound 9) shows an excellent blood exposure after a single dose (100 mg/kg)[1].

Molecular Weight

606.99

Formula

C₂₅H₂₁ClF₂N₆O₆S

SMILES

O=S(C1=CC=C(N[[email protected]](C2=NC=CC=C2Cl)C3=C4OC(F)(F)OC4=CC=C3)C(NC5=NC(OC)=NC(OC)=N5)=C1)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Dot1L-IN-6Histone MethyltransferaseDOT1LH3K79lysinehistonemethyltransferaseInhibitorinhibitorinhibit

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