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NCT-10b

NCT-10b is a selective HDAC6 inhibitor. NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma.

For research use only. We do not sell to patients.

CAS No.: 908860-09-3
Formula: C₂₁H₃₈N₂O₄S
Molecular Weight:414.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NCT-10b Chemical Structure

CAS No.: 908860-09-3

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NCT-10b is a selective HDAC6 inhibitor. NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma^[1].

IC₅₀ & Target^[1]

HDAC6

α-Tubulin

All HDAC Isoforms :

In Vitro

NCT-10b (compound 17b) (0.1-300 μM; 8 h) selectively induces α-tubulin acetylation over histone H4 acetylation in HCT116 cells, with an EC₅₀ of 0.23 μM for α-tubulin acetylation and a selectivity index >140^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0.1; 0.3; 1; 3; 10; 30; 100; 300 μM
Incubation Time:

8 h
Result:

Produced a dose-dependent increase in acetylated α-tubulin without a major increase in acetylated histone H4.
Reached an EC₅₀ value of 0.23 μM for α-tubulin acetylation, and an EC₅₀ value of >32 μM for histone H4 acetylation, resulting in a selectivity index of >140.

Chemical Information

CAS No. 908860-09-3
Molecular Weight 414.61
Formula C₂₁H₃₈N₂O₄S
SMILES

[C@H](C(NC1CCCC1)=O)(NC(OC(C)(C)C)=O)CCCCCSC(C(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Suzuki T, et al. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. J Med Chem. 2006;49(16):4809-4812. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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