NCT-10b

Cat. No.: HY-123699: Data Sheet Handling Instructions
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NCT-10b (compound 17b) is a selective HDAC6 inhibitor.NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma.

For research use only. We do not sell to patients.

NCT-10b Chemical Structure

CAS No. : 908860-09-3

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•Related Small Molecules:

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View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

HDAC6

In Vitro

NCT-10b (compound 17b) (0.01-30 μM; 8 h) selectively induces α-tubulin acetylation over histone H4 acetylation in HCT116 cells, with an EC₅₀ of 0.23 μM for α-tubulin acetylation and a selectivity index >140^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HCT116 cells
Concentration:	0.01-30 μM
Incubation Time:	8 h
Result:	Produced a dose-dependent increase in acetylated α-tubulin without a major increase in acetylated histone H4. Reached an EC₅₀ value of 0.23 μM for α-tubulin acetylation, and an EC₅₀ value of >32 μM for histone H4 acetylation, resulting in a selectivity index (histone acetylation EC₅₀/α-tubulin acetylation EC₅₀) of >140.

Molecular Weight

414.61

Formula

C₂₁H₃₈N₂O₄S

CAS No.

908860-09-3

SMILES

[C@H](C(NC1CCCC1)=O)(NC(OC(C)(C)C)=O)CCCCCSC(C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Suzuki T, et al. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. J Med Chem. 2006;49(16):4809-4812. [Content Brief]

NCT-10b Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCT-10b908860-09-3HDACHistone deacetylaseshistone H4 acetylationHDAC6HCT116 cellsmultiple myelomaHistone Deacetylase 6α-tubulin acetylationInhibitorinhibitorinhibit

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