EZH2-IN-21
EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates.
For research use only. We do not sell to patients.
- CAS No.: 923894-97-7
- Formula: C21H25N5O2
- Molecular Weight:379.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC1806 | IC50 |
10632 nM
Compound: 1
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Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
Inhibition of EZH2-mediated nuclear H3K27 methylation in human HCC1806 cells after 72 hrs by immunofluorescence analysis
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[PMID: 24900432] |
Chemical Information
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CAS No. 923894-97-7
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Molecular Weight 379.46
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Formula C21H25N5O2
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SMILES
O=C(C1=CC(C2CC2)=NC3=C1C=NN3C(C)C)NCC4=C(C)C=C(C)NC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EZH2-IN-21 Related Classifications
HY-113786 Related Classifications
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