923894-97-7
923894-97-7
Chemical Structure
EZH2-IN-21
- CAS No.: 923894-97-7
- Formula:C21H25N5O2
- Molecular Weight:379.46
IUPAC Name: 6-cyclopropyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
InChIKey: HNHUNRACMOTTER-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2CC2)=NC3=C1C=NN3C(C)C)NCC4=C(C)C=C(C)NC4=O
Biological Activity: EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates[1].
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EZH2-IN-21 | EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates. | |||||||||||||||||||||
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References
Keywords
