Mint3 Antibody (YA3242)
(Synonyms: Histone lysine demethylase MINA; MDIG; MINA; NO52; ROX)Mint3 Antibody (YA3242) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mint3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:200 |
Product Details
Mint3 Antibody (YA3242) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mint3.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 53 kDa
Entrez Gene: 84864 Human ; 57267 Mouse ;
SwissProt: Q8IUF8 Human ; O88888 Mouse ;
OMIM: 612049 Human
A synthesized peptide derived from human MINA53 aa416-465.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Mint3 is an Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles
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Subcellular Localization
Nucleus; Nucleus, nucleolus
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Expression
Tissue_specificity:Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC) , and colon cancer tissues, and in various cancer cell lines
Induction:Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treated A549 lung cancer cells -
Isoforms & Post-Translational Modification
Q8IUF8 has 4 isomers: Q8IUF8-1: 52800 Da (predicted); Q8IUF8-2: 31818 Da (predicted); Q8IUF8-3: 23909 Da (predicted); Q8IUF8-4: 52672 Da (predicted).
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SwissProt ID
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Synonyms
Histone lysine demethylase MINA; MDIG; MINA; NO52; ROX
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Research Field
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Documentation
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