RIOX2 - ribosomal oxygenase 2 Gene

Also Known as ROX; MDIG; MINA; NO52; JMJD10; MINA53

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84864

About RIOX2

Cytogenetic location: 3q11.2 Genomic coordinates (GRCh38): 3:97,941,818-97,972,431 (from NCBI)

This gene has 9 transcripts (splice variants), 189 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 23.6), skin (RPKM 10.0) and 24 other tissues.

Summary

MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

RIOX2 Products (4)

mRNA Protein Name
NM_001042533.3 NP_001035998.1 ribosomal oxygenase 2 isoform a
NM_001261829.2 NP_001248758.1 ribosomal oxygenase 2 isoform b
NM_032778.6 NP_116167.3 ribosomal oxygenase 2 isoform b
NM_153182.4 NP_694822.2 ribosomal oxygenase 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables peptidyl-histidine dioxygenase activity EXP
EXP: Inferred from Experiment
23103944 GOA
enables peptidyl-histidine dioxygenase activity IDA
IDA: Inferred from direct assay
23103944 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIOX2 Protein Structure

Cupin_4

Cupin_4: Cupin superfamily protein (52 - 363)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

ribosomal oxygenase 2

  • 60S ribosomal protein L27a histidine hydroxylase

RIOX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RIOX2 Q8IUF8 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
RIOX2 Q8IUF8 tax Human T-cell leukemia virus P03410
Y2H Array
22458338
Intra
RIOX2 Q8IUF8 RIOX2 Homo sapiens Q8IUF8
Y2H Prey Pooling
32296183
Intra
RIOX2 Q8IUF8 RIOX2 Homo sapiens Q8IUF8
Validated Y2H
32296183
Intra
RIOX2 Q8IUF8 RIOX2 Homo sapiens Q8IUF8
Y2H Array
25416956
Intra
RIOX2 Q8IUF8 RIOX2 Homo sapiens Q8IUF8
Y2H Array
32296183
Intra
RIOX2 Q8IUF8 RIOX2 Homo sapiens Q8IUF8
Y2H Pooling
16189514
Intra
RIOX2 Q8IUF8 tax Human T-cell leukemia virus 1 P14079
Y2H Pooling
22458338
Intra
RIOX2 Q8IUF8 tax Human T-cell leukemia virus 1 P14079
Y2H Array
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

RIOX2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83497 Mint3 Antibody (YA3242) WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11991 RIOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RIOX2 VGNC VGNC:45593
Rattus norvegicus RIOX2 RGD RGD:708521
Macaca mulatta RIOX2 VGNC VGNC:76777
Felis catus RIOX2 VGNC VGNC:64639
Bos taurus RIOX2 VGNC VGNC:33980
Mus musculus RIOX2 MGD MGI:1914264
Others RIOX2 NCBI