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Cat. No.: HY-157436

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HDAC6-IN-30

HDAC6-IN-30 (compound 8g) is a selective HDAC6 inhibitor with the IC₅₀ 21 nM, and increase cell protein acetylation levels.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₀N₂O₃
Molecular Weight:360.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HDAC6-IN-30 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HDAC6-IN-30 (compound 8g) is a selective HDAC6 inhibitor with the IC₅₀ 21 nM, and increase cell protein acetylation levels^[1].

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	GI₅₀	80 μM Compound: 8g	Antiproliferative activity against human HeLa cells assessed as growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human HeLa cells assessed as growth inhibition incubated for 72 hrs by MTS assay	[PMID: 38142511]
MDA-MB-231	GI₅₀	87 μM Compound: 8g	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition incubated for 72 hrs by MTS assay	[PMID: 38142511]
NCI-H1975	GI₅₀	13 μM Compound: 8g	Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated for 96 hrs by MTS assay Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated for 96 hrs by MTS assay	[PMID: 38142511]

Chemical Information

Molecular Weight 360.41
Formula C₂₂H₂₀N₂O₃
SMILES

O=C(NO)C(C=C1)=CC=C1CN(C(C2=CC=CC=C2)=O)CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jha S, et al. Design, synthesis, and biological evaluation of HDAC6 inhibitors targeting L1 loop and serine 531 residue. Eur J Med Chem. Published online December 20, 2023. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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