1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. Histone Acetyltransferase
    STAT
  3. L002

L002 

Cat. No.: HY-100671
Handling Instructions

L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation.

For research use only. We do not sell to patients.

L002 Chemical Structure

L002 Chemical Structure

CAS No. : 321695-57-2

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Description

L002 is a novel potent, specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 uM. L002 has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases[1]. L002 blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation[2].

IC50 & Target

IC50: 1.98 uM (KAT3B); 35 µM (PCAF); 34 µM (GCN5)[1] ;STAT3; p53[2]

Molecular Weight

321.35

Formula

C₁₅H₁₅NO₅S

CAS No.

321695-57-2

SMILES

O=C1C(C)=C/C(C=C1C)=N\OS(=O)(C2=CC=C(OC)C=C2)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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L002
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