3-Deazaneplanocin A hydrochloride  (Synonyms: DZNep hydrochloride; NSC 617989 hydrochloride; 3-Deazaneplanocin hydrochloride)

3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor^[1][2].

3-Deazaneplanocin A (20-200 nM, during 16-28 day) stimulates Oct4 expression in chemically induced pluripotent stem cells (CiPSCs)^[2].
3-Deazaneplanocin A (20-200 nM, during 16-28 day) inhibits DNA and H3K9 methylation at the Oct4 promoter in CiPSCs^[2].
3-Deazaneplanocin A (10 nM, 24 h) promotes developmental competence of cloned pig embryos^[3].
3-Deazaneplanocin A (10 nM, 24 h) decreases the levels of H3K27me3 and H3K9me2 at the 2-cell, 4-cell and blastocyst stages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

298.73

C₁₂H₁₅ClN₄O₃

120964-45-6

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fiskus W, et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood. 2009 Sep 24;114(13):2733-43.  [Content Brief]

  [2]. Hou P, et al. Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science. 2013 Aug 9;341(6146):651-4.  [Content Brief]

  [3]. Zhao C, et al. DZNep and UNC0642 enhance in vitro developmental competence of cloned pig embryos. Reproduction. 2018 Apr 1;157(4):359-369.  [Content Brief]