1. Epigenetics
    Apoptosis
  2. Histone Acetyltransferase
    Apoptosis
  3. CTB

CTB (Synonyms: Cholera Toxin B subunit)

Cat. No.: HY-134964
Handling Instructions

CTB (Cholera Toxin B subunit) is a potent p300 histone acetyltransferase activator. CTB can effectively induce apoptosis in MCF-7 cells.

For research use only. We do not sell to patients.

CTB Chemical Structure

CTB Chemical Structure

CAS No. : 451491-47-7

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Description

CTB (Cholera Toxin B subunit) is a potent p300 histone acetyltransferase activator[1]. CTB can effectively induce apoptosis in MCF-7 cells[2].

IC50 & Target[1]

p300

 

In Vitro

CTB (10, 50, 100, 150, 200, and 250 µM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner[1].
CTB (0-200 μM; 24 hours) inhibits the viability of MCF-7 cells with an IC50 of 85.43 μM[2].
CTB (85.43 μM; 24, 48 and 72 h) induces time dependence apoptosis of MCF-7 cells[2].
CTB (50 uM; 24 h) increases p300/CBP activity , and reduces autophagic flux in primary neurons[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7 cell
Concentration: 0-200 μM
Incubation Time: 24 hours
Result: Inhibit viability with an IC50 of 85.43 μM.

Apoptosis Analysis[2]

Cell Line: MCF-7 cell
Concentration: 85.43 μM
Incubation Time: 24, 48 and 72 h
Result: Iinduced time-dependence apoptosis.
Molecular Weight

343.73

Formula

C₁₆H₁₃ClF₃NO₂

CAS No.
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CTB
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HY-134964
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