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Cat. No.: HY-124007

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4-Iodo-SAHA

(Synonyms: ISAHA)

4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer.

For research use only. We do not sell to patients.

Purity: 99.12%
CAS No.: 1219807-87-0
Formula: C₁₄H₁₉IN₂O₃
Molecular Weight:390.22

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

4-Iodo-SAHA Chemical Structure

CAS No.: 1219807-87-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	0.85 μM Compound: 1k	Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
HT-29	EC₅₀	0.95 μM Compound: 1k	Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
Jurkat	EC₅₀	0.24 μM Compound: 1k	Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
K562	EC₅₀	1.3 μM Compound: 1k	Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
SK-BR-3	EC₅₀	1.1 μM Compound: 1k	Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
U-937	EC₅₀	0.12 μM Compound: 1k	Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]

In Vitro

4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines ^[1].
4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

SKBR3, HT29, U937, JA16 and HL60 cell lines
Concentration:

0.1-100 μM
Incubation Time:

48 h
Result:

Inhibited SKBR3, HT29, U937, JA16 and HL60 cell lines with EC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM , respectively. Showed 10-fold potent as an inhibitor of U937 cell line compared to SAHA.

Western Blot Analysis^[1]

Cell Line:

SKBR3-breast-derived cell line
Concentration:

2 μM
Incubation Time:

6, 12 and 24 h
Result:

Time-dependently up regulated histone H4 acetylation and p21/WAF1 cell cycle inhibitor accumulation in SKBR3 cells.

In Vivo

4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-week-old fvb mice^[1]
Dosage:

50 mg/kg
Administration:

Oral gavage; 50 mg/kg five times per week; for 2 weeks
Result:

Compared to both SAHA-treated and control mice with similar body weights and hematological counts.

Chemical Information

CAS No. 1219807-87-0
Appearance Solid
Molecular Weight 390.22
Formula C₁₄H₁₉IN₂O₃
Color White to off-white
SMILES

IC1=CC=C(C=C1)NC(CCCCCCC(NO)=O)=O
Synonyms

ISAHA
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Salmi-Smail C, et al. Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. J Med Chem. 2010 Apr 22;53(8):3038-47. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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4-Iodo-SAHA

Bioactive Compound Library Max

Bioactive Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Anti-Hematopathy Compound Library

MCE Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

4-Iodo-SAHA

Bioactive Compound Library Max

Bioactive Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Orally Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Anti-Hematopathy Compound Library

MCE Bioactive Compound Library

Anti-Brain Cancer Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

4-Iodo-SAHA Related Classifications

HY-124007 Related Classifications