4-Iodo-SAHA (Synonyms: ISAHA)

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4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer.

For research use only. We do not sell to patients.

4-Iodo-SAHA Chemical Structure

CAS No. : 1219807-87-0

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines ^[1].
4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	SKBR3, HT29, U937, JA16 and HL60 cell lines
Concentration:	0.1-100 μM
Incubation Time:	48 h
Result:	Inhibited SKBR3, HT29, U937, JA16 and HL60 cell lines with EC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM , respectively. Showed 10-fold potent as an inhibitor of U937 cell line compared to SAHA.

Western Blot Analysis^[1]

Cell Line:	SKBR3-breast-derived cell line
Concentration:	2 μM
Incubation Time:	6, 12 and 24 h
Result:	Time-dependently up regulated histone H4 acetylation and p21/WAF1 cell cycle inhibitor accumulation in SKBR3 cells.

In Vivo

4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-week-old fvb mice^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage; 50 mg/kg five times per week; for 2 weeks
Result:	Compared to both SAHA-treated and control mice with similar body weights and hematological counts.

Molecular Weight

390.22

Formula

C₁₄H₁₉IN₂O₃

CAS No.

1219807-87-0

SMILES

IC1=CC=C(C=C1)NC(CCCCCCC(NO)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Salmi-Smail C, et al. Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity. J Med Chem. 2010 Apr 22;53(8):3038-47. [Content Brief]

4-Iodo-SAHA Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Iodo-SAHA1219807-87-0ISAHAHDACHistone deacetylasesoralantileukemiaSAHAantiproliferative activitycancerInhibitorinhibitorinhibit

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