MJP6412
Based on 1 Customer Validation
MJP6412 is a potent degrader histone acetyltransferases p300/CBP, with DC50 of 1.6 and 1.2 nM for p300 and CBP, respectively. MJP6412 plays an important role in cancer research.
(Pink: CBP/p300 ligand (HY-111784); Blue: Cereblon ligand (HY-W087383); Black: linker (HY-W102095)).
For research use only. We do not sell to patients.
- Purity: 95.90%
- CAS No.: 3105406-14-9
- Formula: C55H54F2N8O9
- Molecular Weight:1009.06
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Chemical Information
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CAS No. 3105406-14-9
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Appearance Solid
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Molecular Weight 1009.06
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Formula C55H54F2N8O9
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Color Light yellow to yellow
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SMILES
O=C(CCC1N(C(C2=C3C=CC(N4CCC(CC4)OC5=CC=C(C=C5)NC(CO[C@H]6CC[C@H](N7C([C@H]8N(C9=CC(F)=C(F)C=C9)C(CCC8)=O)=NC%10=CC(C%11=C(C)ON=C%11C)=CC=C7%10)CC6)=O)=C2)=O)C3=O)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (99.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.48 mM); Suspended solution
This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9910 mL | 4.9551 mL | 9.9102 mL | 24.7755 mL |
| 5 mM | 0.1982 mL | 0.9910 mL | 1.9820 mL | 4.9551 mL | |
| 10 mM | 0.0991 mL | 0.4955 mL | 0.9910 mL | 2.4776 mL | |
| 15 mM | 0.0661 mL | 0.3303 mL | 0.6607 mL | 1.6517 mL | |
| 20 mM | 0.0496 mL | 0.2478 mL | 0.4955 mL | 1.2388 mL | |
| 25 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9910 mL | |
| 30 mM | 0.0330 mL | 0.1652 mL | 0.3303 mL | 0.8259 mL | |
| 40 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6194 mL | |
| 50 mM | 0.0198 mL | 0.0991 mL | 0.1982 mL | 0.4955 mL | |
| 60 mM | 0.0165 mL | 0.0826 mL | 0.1652 mL | 0.4129 mL | |
| 80 mM | 0.0124 mL | 0.0619 mL | 0.1239 mL | 0.3097 mL |
MJP6412 Related Classifications
HY-168201 Related Classifications
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