LEM-14-1189
Based on 1 Customer Validation
LEM-14-1189, a LEM-14 (HY-114340) derivative, is a NSDs inhibitor with IC50s of 418 μM (NSD1), 111 μM (NSD2), and 60 μM (NSD3), respectively. The NSDs, histone lysine methyltransferases (HMTases), are oncoproteins, drivers of a number of tumors. LEM-14-1189 can be used for multiple myeloma (MM) research.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 2987501-17-5
- Formula: C35H34N6O5S2
- Molecular Weight:682.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
418 μM (NSD1), 111 μM (NSD2), and 60 μM (NSD3)[1]
Chemical Information
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CAS No. 2987501-17-5
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Appearance Solid
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Molecular Weight 682.81
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Formula C35H34N6O5S2
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Color White to off-white
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SMILES
O=C(C(OC1=O)=CC2=C1C=CC=C2)NCCCN(CC3=NC4=C(C5=C(CCCC5)S4)C(N3)=O)CC6=NC7=C(C8=C(CCCC8)S7)C(N6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (146.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4645 mL | 7.3227 mL | 14.6454 mL | 36.6134 mL |
| 5 mM | 0.2929 mL | 1.4645 mL | 2.9291 mL | 7.3227 mL | |
| 10 mM | 0.1465 mL | 0.7323 mL | 1.4645 mL | 3.6613 mL | |
| 15 mM | 0.0976 mL | 0.4882 mL | 0.9764 mL | 2.4409 mL | |
| 20 mM | 0.0732 mL | 0.3661 mL | 0.7323 mL | 1.8307 mL | |
| 25 mM | 0.0586 mL | 0.2929 mL | 0.5858 mL | 1.4645 mL | |
| 30 mM | 0.0488 mL | 0.2441 mL | 0.4882 mL | 1.2204 mL | |
| 40 mM | 0.0366 mL | 0.1831 mL | 0.3661 mL | 0.9153 mL | |
| 50 mM | 0.0293 mL | 0.1465 mL | 0.2929 mL | 0.7323 mL | |
| 60 mM | 0.0244 mL | 0.1220 mL | 0.2441 mL | 0.6102 mL | |
| 80 mM | 0.0183 mL | 0.0915 mL | 0.1831 mL | 0.4577 mL | |
| 100 mM | 0.0146 mL | 0.0732 mL | 0.1465 mL | 0.3661 mL |
LEM-14-1189 Related Classifications
HY-125244 Related Classifications
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