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Art. -Nr.: HY-174393

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Gamhepathiopine

Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Q_o site of Plasmodium falciparum cytochrome b and inhibiting the activity of complex III in the electron transport chain.

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CAS. Nr.: 1620442-30-9
Formel: C₁₇H₁₉N₃OS
Molecular Weight:313.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Gamhepathiopine Chemical Structure

CAS. Nr.: 1620442-30-9

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	CC₅₀	27.5 μM Compound: 1	Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against CHO cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 25791675]
Hepatocyte	CC₅₀	>200 μM Compound: 1	Cytotoxicity against cynomolgus monkey Primary hepatocyte assessed as cell viability Cytotoxicity against cynomolgus monkey Primary hepatocyte assessed as cell viability	[PMID: 36680984]
HepG2	CC₅₀	25.6 μM Compound: 1	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 25791675]

Chemical Information

CAS. Nr. 1620442-30-9
Molecular Weight 313.42
Formel C₁₇H₁₉N₃OS
SMILES

CC1=CC=C(C2=CC(N=C(NC(C)(C)C)NC3=O)=C3S2)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wiedemar N, et al. The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b. ACS Infect Dis. 2025 Jun 13;11(6):1719-1728. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Gamhepathiopine

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Biologische Aktivität

Chemical Information

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Calculators

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Gamhepathiopine Related Classifications

HY-174393 Related Classifications