2. Epigenetics
  3. Epigenetic Reader Domain
  4. PFI-6

PFI-6 is a selective MLLT1 and MLLT3 YEATS domain probe with IC50 values of 0.14 μM and 0.16 μM, respectively. PFI-6 is applicable for cancer research.

For research use only. We do not sell to patients.

PFI-6

PFI-6 Chemical Structure

CAS No. : 2675452-91-0

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Based on 1 publication(s) in Google Scholar

PFI-6 Related Antibodies

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Description

PFI-6 is a selective MLLT1 and MLLT3 YEATS domain probe with IC50 values of 0.14 μM and 0.16 μM, respectively. PFI-6 is applicable for cancer research[1].

IC50 & Target[1]

MLLT1

0.14 μM (IC50)

MLLT3

0.16 μM (IC50)

In Vitro

PFI-6 potently and selectively binds to the YEATS domains of MLLT1 and MLLT3, with corresponding IC50 values of 0.14 μM and 0.16 μM[1].
PFI-6 binds to endogenous MLLT3 in HEK293 cells with an IC50 of 0.76 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PFI-6 Related Antibodies
Molecular Weight

391.42

Formula

C22H21N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C)C)C1=CC=C(C2=CC(C(N[C@H]3C(C=CC=C4)=C4CC3)=O)=NO2)C=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (63.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5548 mL 12.7740 mL 25.5480 mL
5 mM 0.5110 mL 2.5548 mL 5.1096 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

SDS (393 KB)

COA (248 KB) HNMR (471 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5548 mL 12.7740 mL 25.5480 mL 63.8700 mL
5 mM 0.5110 mL 2.5548 mL 5.1096 mL 12.7740 mL
10 mM 0.2555 mL 1.2774 mL 2.5548 mL 6.3870 mL
15 mM 0.1703 mL 0.8516 mL 1.7032 mL 4.2580 mL
20 mM 0.1277 mL 0.6387 mL 1.2774 mL 3.1935 mL
25 mM 0.1022 mL 0.5110 mL 1.0219 mL 2.5548 mL
30 mM 0.0852 mL 0.4258 mL 0.8516 mL 2.1290 mL
40 mM 0.0639 mL 0.3194 mL 0.6387 mL 1.5968 mL
50 mM 0.0511 mL 0.2555 mL 0.5110 mL 1.2774 mL
60 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0645 mL
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PFI-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PFI-62675452-91-0PFI6PFI 6Epigenetic Reader Domainnephroblastomalymphoid neoplasmYEATS4YEATS2YEATS domainMLLT1histone KAc recognition sitegliomaacute myeloid leukemiaMLLT3Inhibitorinhibitorinhibit

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