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Cat. No.: HY-139795

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ZYJ-25e

ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC₅₀s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model.

For research use only. We do not sell to patients.

CAS No.: 1287261-04-4
Formula: C₃₀H₄₀N₄O₈
Molecular Weight:584.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ZYJ-25e Chemical Structure

CAS No.: 1287261-04-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC6

0.047 μM (IC₅₀)

HDAC8

0.139 μM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.94 μM Compound: 25e	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21476600]
HeLa	IC₅₀	0.047 μM Compound: 25e	Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader	[PMID: 21476600]
HeLa	IC₅₀	0.058 μM Compound: 25e	Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader	[PMID: 21476600]
HeLa	IC₅₀	37.1 μM Compound: 25e	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21476600]
HL-60	IC₅₀	47.6 μM Compound: 25e	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 21476600]
K562	IC₅₀	1.47 μM Compound: 25e	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 21476600]
MDA-MB-231	IC₅₀	0.79 μM Compound: 25e	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 21476600]
NB-4	IC₅₀	1.5 μM Compound: 25e	Cytotoxicity against human NB4 cells after 48 hrs by MTT assay Cytotoxicity against human NB4 cells after 48 hrs by MTT assay	[PMID: 21476600]

Chemical Information

CAS No. 1287261-04-4
Molecular Weight 584.66
Formula C₃₀H₄₀N₄O₈
SMILES

CC(C)(C)OC(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CC2=CC=C(OCC(NO)=O)C=C2C1)C(NC3=CC=C(C=C3)OC)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yingjie Zhang, et al. Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. J Med Chem. 2011 Aug 11;54(15):5532-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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ZYJ-25e

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ZYJ-25e Related Classifications

HY-139795 Related Classifications