1287261-04-4
Chemical Structure
ZYJ-25e
- CAS No.: 1287261-04-4
- Formula:C30H40N4O8
- Molecular Weight:584.66
IUPAC Name: tert-butyl ((2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-yl)carbamate
InChIKey: UZZNWMWOBYWIST-SQOVJYTMSA-N
SMILES: CC(C)(C)OC(N[C@@H]([C@@H](C)CC)C(N1[C@@H](CC2=CC=C(OCC(NO)=O)C=C2C1)C(NC3=CC=C(C=C3)OC)=O)=O)=O
Biological Activity: ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC50s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model[1].
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ZYJ-25e | ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC50s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model. | |||||||||||||||||||||
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