DiMethyl-Histone H3 (Lys4) Antibody
(Synonyms: H3K27me3; H3 histone; HIST1H3A; Histone cluster 1; H3a)
Based on 1 Customer Validation
DiMethyl-Histone H3 (Lys4) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DiMethyl-Histone H3 (Lys4).
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P, FC, Dot Blot
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.2% BSA, 40% Glycerol, 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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Dot Blot
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|---|---|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:500-5000 | 1:50-200 | 1:50-1000 | 1:1000 |
Product Details
DiMethyl-Histone H3 (Lys4) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DiMethyl-Histone H3 (Lys4).
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 15 kDa
Synthetic peptide of the N terminal residues of Human Di-mehtyl-Histone H3(Lys4).
Endogenous
affinity purified
Non-conjugated
Methylated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.2% BSA, 40% Glycerol, 0.05% Sodium Azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DiMethyl-Histone H3 core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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Subcellular Localization
Nucleus; Chromosome
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Subunit
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with TONSL; CHAF1A; CHAF1B; MCM2 and DNAJC9 (PubMed:33857403). Interacts with NASP; NASP is a histone chaperone that stabilizes and maintains a soluble pool of Histone H3-H4 dimers (PubMed:22195965)
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SwissProt ID
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Synonyms
H3K27me3; H3 histone; HIST1H3A; Histone cluster 1; H3a
Documentation
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