H3C1 - H3 clustered histone 1 Gene
Also Known as H3/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A
Species: Homo sapiens
About H3C1
This gene has 1 transcript (splice variant), 96 orthologues and 20 paralogues.
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
H3C1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003529.3 | NP_003520.1 | histone H3.1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IDA
IDA: Inferred from direct assay
|
30867594 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10949293 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in epigenetic regulation of gene expression |
IDA
IDA: Inferred from direct assay
|
16267050 | GOA |
| acts upstream of positive effect gene expression |
IDA
IDA: Inferred from direct assay
|
30867594 | GOA |
| involved in nucleosome assembly |
IDA
IDA: Inferred from direct assay
|
14718166 | GOA |
| involved in nucleosome assembly |
IMP
IMP: Inferred from mutant phenotype
|
25615412 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of nucleosome |
IDA
IDA: Inferred from direct assay
|
14718166 | GOA |
| part of nucleosome |
IPI
IPI: Inferred from physical interaction
|
21812398 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
21636898 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
14718166 | GOA |
H3C1 Protein Structure
Histone: Core histone H2A/H2B/H3/H4 (58 - 132)
- 0
- 100
- 136 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
histone H3.1 |
|
H3C1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
H3C1 | P68431 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
H3C1 | P68431 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
H3C1 | P68431 | DNM2 | Homo sapiens | P50570-2 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PSEN1 | Homo sapiens | P49768-2 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PSEN1 | Homo sapiens | P49768-2 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PSEN1 | Homo sapiens | P49768-2 | 32814053 | |
|
Intra
|
H3C1 | P68431 | SETD7 | Homo sapiens | Q8WTS6 | 12540855 | |
|
Intra
|
H3C1 | P68431 | SETD7 | Homo sapiens | Q8WTS6 | 12540855 | |
|
Intra
|
H3C1 | P68431 | CDYL | Homo sapiens | Q9Y232 | 16415788 | |
|
Intra
|
H3C1 | P68431 | AIRE | Homo sapiens | O43918 | 18292755 | |
|
Intra
|
H3C1 | P68431 | AIRE | Homo sapiens | O43918 | 18292755 | |
|
Intra
|
H3C1 | P68431 | AIRE | Homo sapiens | O43918 | 18292755 | |
|
Intra
|
H3C1 | P68431 | PSEN2 | Homo sapiens | P49810 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PSEN2 | Homo sapiens | P49810 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PSEN2 | Homo sapiens | P49810 | 32814053 | |
|
Intra
|
H3C1 | P68431 | CTSD | Homo sapiens | P07339 | 32814053 | |
|
Intra
|
H3C1 | P68431 | CTSD | Homo sapiens | P07339 | 32814053 | |
|
Intra
|
H3C1 | P68431 | CTSD | Homo sapiens | P07339 | 32814053 | |
|
Cross
|
H3C1 | P68431 | SGF29 | Saccharomyces cerevisiae | P25554 | 21685874 | |
|
Cross
|
H3C1 | P68431 | SGF29 | Saccharomyces cerevisiae | P25554 | 21685874 | |
|
Cross
|
H3C1 | P68431 | SGF29 | Saccharomyces cerevisiae | P25554 | 21685874 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 32296183 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 29568061 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 29568061 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 32296183 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 19410544 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 25281560 | |
|
Intra
|
H3C1 | P68431 | DNAJC9 | Homo sapiens | Q8WXX5 | 32296183 | |
|
Intra
|
H3C1 | P68431 | PHF20 | Homo sapiens | Q9BVI0 | 16415788 | |
|
Intra
|
H3C1 | P68431 | PHF20 | Homo sapiens | Q9BVI0 | 16415788 | |
|
Intra
|
H3C1 | P68431 | MPHOSPH8 | Homo sapiens | Q99549 | 20871592 | |
|
Intra
|
H3C1 | P68431 | ING4 | Homo sapiens | Q9UNL4 | 17157298 | |
|
Intra
|
H3C1 | P68431 | H4C16 | Homo sapiens | P62805 | 28514442 | |
|
Intra
|
H3C1 | P68431 | H4C16 | Homo sapiens | P62805 | 19410544 | |
|
Intra
|
H3C1 | P68431 | H4C16 | Homo sapiens | P62805 | 25416956 | |
|
Intra
|
H3C1 | P68431 | H4C16 | Homo sapiens | P62805 | 19498464 | |
|
Intra
|
H3C1 | P68431 | YWHAZ | Homo sapiens | P63104 | 19766566 | |
|
Intra
|
H3C1 | P68431 | YWHAZ | Homo sapiens | P63104 | 16246723 | |
|
Intra
|
H3C1 | P68431 | YWHAZ | Homo sapiens | P63104 | 18418070 | |
|
Intra
|
H3C1 | P68431 | MCM2 | Homo sapiens | P49736 | 26167883 | |
|
Intra
|
H3C1 | P68431 | MCM2 | Homo sapiens | P49736 | 28514442 | |
|
Intra
|
H3C1 | P68431 | FBLIM1 | Homo sapiens | Q8WUP2 | 25416956 | |
|
Intra
|
H3C1 | P68431 | FBLIM1 | Homo sapiens | Q8WUP2 | 25416956 | |
|
Intra
|
H3C1 | P68431 | TP53BP1 | Homo sapiens | Q12888 | 16415788 | |
|
Intra
|
H3C1 | P68431 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
H3C1 | P68431 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
H3C1 | P68431 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PKM | Homo sapiens | P14618-1 | 24606918 | |
|
Intra
|
H3C1 | P68431 | HTT | Homo sapiens | P42858 | 23275563 | |
|
Intra
|
H3C1 | P68431 | HTT | Homo sapiens | P42858 | 23275563 | |
|
Intra
|
H3C1 | P68431 | WDR5 | Homo sapiens | P61964 | 16946699 | |
|
Intra
|
H3C1 | P68431 | KMT2A | Homo sapiens | Q03164 | 20541251 | |
|
Intra
|
H3C1 | P68431 | KMT2A | Homo sapiens | Q03164 | 20541251 | |
|
Intra
|
H3C1 | P68431 | KMT2A | Homo sapiens | Q03164 | 20541251 | |
|
Intra
|
H3C1 | P68431 | A2M | Homo sapiens | P01023 | 32814053 | |
|
Intra
|
H3C1 | P68431 | A2M | Homo sapiens | P01023 | 32814053 | |
|
Intra
|
H3C1 | P68431 | A2M | Homo sapiens | P01023 | 32814053 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321-2 | 19498464 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321-2 | 25416956 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321-2 | 25416956 | |
|
Intra
|
H3C1 | P68431 | TTR | Homo sapiens | P02766 | 32814053 | |
|
Intra
|
H3C1 | P68431 | TTR | Homo sapiens | P02766 | 32814053 | |
|
Intra
|
H3C1 | P68431 | TTR | Homo sapiens | P02766 | 32814053 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321 | 29568061 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321 | 29568061 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321 | 20080577 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321 | 19410544 | |
|
Intra
|
H3C1 | P68431 | NASP | Homo sapiens | P49321 | 25281560 | |
|
Intra
|
H3C1 | P68431 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
H3C1 | P68431 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
H3C1 | P68431 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
H3C1 | P68431 | SGF29 | Homo sapiens | Q96ES7 | 21685874 | |
|
Intra
|
H3C1 | P68431 | SGF29 | Homo sapiens | Q96ES7 | 21685874 | |
|
Intra
|
H3C1 | P68431 | SGF29 | Homo sapiens | Q96ES7 | 21685874 | |
|
Intra
|
H3C1 | P68431 | CBX1 | Homo sapiens | P83916 | 29568061 | |
|
Intra
|
H3C1 | P68431 | CBX1 | Homo sapiens | P83916 | 16415788 | |
|
Intra
|
H3C1 | P68431 | CBX1 | Homo sapiens | P83916 | 16415788 | |
|
Intra
|
H3C1 | P68431 | CBX5 | Homo sapiens | P45973 | 25281560 | |
|
Intra
|
H3C1 | P68431 | CBX5 | Homo sapiens | P45973 | 20871592 | |
|
Intra
|
H3C1 | P68431 | CBX5 | Homo sapiens | P45973 | 19498464 | |
|
Intra
|
H3C1 | P68431 | CBX5 | Homo sapiens | P45973 | 28514442 | |
|
Cross
|
H3C1 | P68431 | IPL1 | Saccharomyces cerevisiae | P38991 | 10949293 | |
|
Intra
|
H3C1 | P68431 | KDM4A | Homo sapiens | O75164 | 16415788 | |
|
Intra
|
H3C1 | P68431 | KDM4A | Homo sapiens | O75164 | 16603238 | |
|
Intra
|
H3C1 | P68431 | KDM4A | Homo sapiens | O75164 | 16415788 | |
|
Intra
|
H3C1 | P68431 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Intra
|
H3C1 | P68431 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Cross
|
H3C1 | P68431 | rhi | Drosophila melanogaster | Q7JXA8 | 25613572 |
Recombinant H3C1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72332 | Histone H3 Protein, Human | P68431 (A2-A136) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72335 | Histone H3 Protein, Human (98a.a, His) | P68431 (P39-A136) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72798 | Histone H3 Protein, Human (His) | P68431 (A2-A136) | ≥ 90%, as determined by reducing SDS-PAGE. |
H3C1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80166 | Histone H3 Antibody (YA368) | WB, ICC/IF, IHC-P, IP, ChIP | Human, Mouse, Rat |
| HY-P80167 | Histone H3 (acetyl K14) Antibody (YA375) | WB, ICC/IF, IHC-P, IP, ChIP | Human, Mouse, Rat |
| HY-P80168 | Histone H3 (acetyl K18) Antibody (YA736) | WB, IHC-P | Human, Rat |
| HY-P80169 | Histone H3 (acetyl K27) Antibody (YA735) | WB, ICC/IF, IHC-P, FC | Human, Mouse, Rat |
| HY-P80170 | Histone H3 (acetyl K56) Antibody (YA374) | WB, ICC/IF, IHC-P, ChIP | Human, Mouse |
| HY-P80171 | Histone H3 (di methyl K9) Antibody (YA373) | WB, ICC/IF, IHC-P | Human, Mouse, Rat |
| HY-P80172 | Histone H3 (mono methyl K18) Antibody (YA372) | WB, ICC/IF, IHC-P | Human, Mouse |
| HY-P80173 | Histone H3 (mono methyl K36)Antibody (YA371) | WB, ICC/IF | Human, Mouse |
| HY-P80174 | Histone H3 (mono methyl R2)Antibody (YA370) | WB, ICC/IF | Human, Mouse |
| HY-P80175 | Histone H3 (mono+di+tri methyl K79) Antibody (YA369) | WB, IHC-P | Human, Mouse, Rat |
| HY-P80176 | Histone H3 (tri methyl K9) Antibody (YA734) | WB, IHC-P, ICC/IF, IF-Tissue | Human, Mouse, Rat |
| HY-P80529 | Acetyl-Histone H3 (Lys14) Antibody (YA643) | WB, ICC/IF, IP | Human, Rat |
| HY-P80529A | Acetyl-Histone H3 (Lys14) Antibody (YA643)(PBS only) | WB, ICC/IF, IP | Human, Rat |
| HY-P80530 | Acetyl-Histone H3 (Lys27) Antibody (YA642) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P80530A | Acetyl-Histone H3 (Lys27) Antibody (YA642)(PBS only) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P80531 | Acetyl-Histone H3 (Lys4) Antibody (YA641) | WB, ICC/IF | Human, Mouse |
| HY-P80531A | Acetyl-Histone H3 (Lys4) Antibody (YA641)(PBS only) | WB, ICC/IF | Human, Mouse |
| HY-P80643 | DiMethyl-Histone H3 Antibody (YA783) | WB, ICC/IF, IP | Human, Mouse, Rat |
| HY-P80643A | DiMethyl-Histone H3 Antibody (YA783)(PBS only) | WB, ICC/IF, IP | Human, Mouse, Rat |
| HY-P80922 | TriMethyl-Histone H3 (Lys27) Antibody (YA030) | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P80922A | TriMethyl-Histone H3 (Lys27) Antibody (YA030)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, IP, ChIP | Human, Rat |
| HY-P810556 | TriMethyl-Histone H3 (Lys27) Antibody (YA9825) | WB, ICC/IF, IHC-P, IF-Tissue, ChIP | Human, Mouse, Rat |
| HY-P810557 | MonoMethyl-Histone H3 (Lys9) Antibody (YA9826) | WB, ICC/IF, IHC-P, FC, ChIP, IF-Tissue, Dot Blot | Human, Mouse, Rat, Monkey |
| HY-P810558 | Acetyl-Histone H3 (Lys18) Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P810559 | MonoMethyl-Histone H3 (Lys4) Antibody | WB, ICC/IF, IHC-P, FC, Dot Blot | Human, Mouse, Rat |
| HY-P810560 | DiMethyl-Histone H3 (Lys4) Antibody | WB, ICC/IF, IHC-P, FC, Dot Blot | Human, Mouse, Rat |
| HY-P810561 | Acetyl-Histone H3 (Lys9) Antibody (YA9827) | WB, ICC/IF, IHC-P, IF-Tissue, FC, ChIP, Dot Blot, IP | Human, Mouse, Rat |
| HY-P810562 | Mono+Di+TriMethyl-Histone H3 (Lys36) Antibody (YA9828) | WB, IHC-P, ICC/IF, FC, ChIP | Human, Mouse, Rat |
| HY-P810563 | Phospho-Histone H3 (Ser28) Antibody (YA9829) | WB, ICC/IF, IHC-P, FC, ChIP | Human, Mouse, Rat |
| HY-P810564 | Acetyl-Histone H3 (Lys4) Antibody (YA9830) | WB, ICC/IF, ChIP, Dot Blot | Human, Mouse, Rat |
| HY-P810565 | DiMethyl-Histone H3 (Lys27) Antibody (YA9831) | WB, ICC/IF, ChIP | Human, Mouse, Rat |
| HY-P810566 | Acetyl-Histone H3 (Lys23) Antibody (YA9832) | WB, ICC/IF | Human, Mouse |
| HY-P810567 | MonoMethyl-Histone H3 (Lys4) Antibody (YA9833) | WB, ICC/IF, ChIP, Dot Blot | Human, Mouse, Rat |
| HY-P810568 | Acetyl-Histone H3 (Lys36) Antibody (YA9834) | WB, IHC-P, ICC/IF, ChIP | Human, Mouse, Rat |
| HY-P810569 | Phospho-Histone H3 (Ser10) Antibody (YA9835) | WB, ICC/IF, IHC-P, IP, FC, ChIP | Human, Mouse, Rat |
| HY-P810570 | DiMethyl-Histone H3 (Lys4) Antibody (YA9836) | WB, ICC/IF, ChIP, Dot Blot, IHC-P | Human, Mouse, Rat, Monkey |
| HY-P810571 | MonoMethyl-Histone H3 (Lys14) Antibody (YA9837) | WB, ICC/IF, ChIP, Dot Blot | Human, Mouse, Rat, Monkey |
| HY-P810572 | Acetyl-Histone H3 (Lys27) Antibody | WB, IHC-P, ICC/IF, ChIP | Human, Mouse, Rat |
| HY-P810573 | Mono+Di+TriMethyl-Histone H3 (Lys4) Antibody (YA9838) | WB, IHC-P, ICC/IF, FC, ChIP | Human, Mouse, Rat |
| HY-P810574 | MonoMethyl-Histone H3 (Lys79) Antibody (YA9839) | WB, ICC/IF, IHC-P, FC, ChIP | Human, Mouse, Rat, Monkey |
| HY-P810575 | TriMethyl-Histone H3 (Lys36) Antibody (YA9840) | WB, IHC-P, ICC/IF, IP, Dot Blot, ChIP | Human, Mouse, Rat, Monkey |
| HY-P85644 | Histone H3 Antibody(HRP) (YA5336) | WB | Zebrafish |
| HY-P85652 | Histone H3 Antibody (YA5344) | WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P85670 | Histone H3 (Di Methyl Lys79) Antibody (YA5362) | WB | Human, Mouse, Rat |
| HY-P85671 | Histone H3 (Tri Methyl Lys36) Antibody (YA5363) | WB, IP | Human, Mouse, Rat |
| HY-P86071 | Histone H3 (Tri Methyl Lys36) Antibody (YA5763) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86113 | Histone H3 (Di Methyl Lys4) Antibody (YA5805) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86144 | Histone H3 (Acetyl Lys36) Antibody (YA5836) | WB, IHC-P, ICC/IF, IP, ChIP, ELISA | Human, Mouse, Rat |
| HY-P86148 | Histone H3 (Di Methyl Lys9) Antibody (YA5840) | WB, IHC-P, ICC/IF, IP, ChIP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Glioma Susceptibility 1 |
|
|
| Plasma Cell Neoplasm |
|
|
| Myeloma, Multiple |
|
|
| Histone Mutated Tumor |
|
|
| Adult Infiltrating Astrocytic Neoplasm |
|
|
| Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted |
|
|
| Diffuse Midline Glioma, H3 K27m-Mutant |
|
|
| Brain Stem Cancer |
|
|
| Hutchinson-Gilford Progeria Syndrome |
|
|
| Childhood Brain Stem Glioma |
|
|
| Brain Stem Glioma |
|
|
| Diffuse Large B-Cell Lymphoma |
|
|
| Posterior Fossa Ependymoma |
|
|
| Glioblastoma |
|
|
| Adult Astrocytic Tumour |
|
|
| Pilomyxoid Astrocytoma |
|
|
| Low Grade Glioma |
|
|
| Pilocytic Astrocytoma |
|
|
| Central Nervous System Benign Neoplasm |
|
|
| Medulloblastoma |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | H3C1 | RGD | RGD:1598076 |
| Mus musculus | H3C1 | MGD | MGI:2668828 |