H3C1 - H3 clustered histone 1 Gene

Also Known as H3/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8350

About H3C1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,020,451-26,020,958 (from NCBI)

This gene has 1 transcript (splice variant), 96 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3C1 Products (1)

mRNA Protein Name
NM_003529.3 NP_003520.1 histone H3.1
Molecular Function GO Annotation Evidence References Source
enables protein binding IDA
IDA: Inferred from direct assay
30867594 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10949293 GOA
Biological Process GO Annotation Evidence References Source
involved in epigenetic regulation of gene expression IDA
IDA: Inferred from direct assay
16267050 GOA
acts upstream of positive effect gene expression IDA
IDA: Inferred from direct assay
30867594 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
25615412 GOA
Cellular Component GO Annotation Evidence References Source
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
21812398 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21636898 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3C1 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.1

  • H3 histone family, member A

H3C1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H3C1 P68431 DNM2 Homo sapiens P50570-2 32814053
Intra
H3C1 P68431 DNM2 Homo sapiens P50570-2 32814053
Intra
H3C1 P68431 DNM2 Homo sapiens P50570-2 32814053
Intra
H3C1 P68431 PSEN1 Homo sapiens P49768-2 32814053
Intra
H3C1 P68431 PSEN1 Homo sapiens P49768-2 32814053
Intra
H3C1 P68431 PSEN1 Homo sapiens P49768-2 32814053
Intra
H3C1 P68431 SETD7 Homo sapiens Q8WTS6
NMR
12540855
Intra
H3C1 P68431 SETD7 Homo sapiens Q8WTS6 12540855
Intra
H3C1 P68431 CDYL Homo sapiens Q9Y232 16415788
Intra
H3C1 P68431 AIRE Homo sapiens O43918 18292755
Intra
H3C1 P68431 AIRE Homo sapiens O43918
NMR
18292755
Intra
H3C1 P68431 AIRE Homo sapiens O43918
ITC
18292755
Intra
H3C1 P68431 PSEN2 Homo sapiens P49810 32814053
Intra
H3C1 P68431 PSEN2 Homo sapiens P49810 32814053
Intra
H3C1 P68431 PSEN2 Homo sapiens P49810 32814053
Intra
H3C1 P68431 CTSD Homo sapiens P07339 32814053
Intra
H3C1 P68431 CTSD Homo sapiens P07339 32814053
Intra
H3C1 P68431 CTSD Homo sapiens P07339 32814053
Cross
H3C1 P68431 SGF29 Saccharomyces cerevisiae P25554
SPR
21685874
Cross
H3C1 P68431 SGF29 Saccharomyces cerevisiae P25554
FPS
21685874
Cross
H3C1 P68431 SGF29 Saccharomyces cerevisiae P25554 21685874
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5 32296183
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5 29568061
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5 29568061
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5 32296183
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5
TAP
19410544
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5 25281560
Intra
H3C1 P68431 DNAJC9 Homo sapiens Q8WXX5 32296183
Intra
H3C1 P68431 PHF20 Homo sapiens Q9BVI0 16415788
Intra
H3C1 P68431 PHF20 Homo sapiens Q9BVI0
SPR
16415788
Intra
H3C1 P68431 MPHOSPH8 Homo sapiens Q99549 20871592
Intra
H3C1 P68431 ING4 Homo sapiens Q9UNL4
NMR
17157298
Intra
H3C1 P68431 H4C16 Homo sapiens P62805 28514442
Intra
H3C1 P68431 H4C16 Homo sapiens P62805
TAP
19410544
Intra
H3C1 P68431 H4C16 Homo sapiens P62805 25416956
Intra
H3C1 P68431 H4C16 Homo sapiens P62805 19498464
Intra
H3C1 P68431 YWHAZ Homo sapiens P63104 19766566
Intra
H3C1 P68431 YWHAZ Homo sapiens P63104 16246723
Intra
H3C1 P68431 YWHAZ Homo sapiens P63104 18418070
Intra
H3C1 P68431 MCM2 Homo sapiens P49736 26167883
Intra
H3C1 P68431 MCM2 Homo sapiens P49736 28514442
Intra
H3C1 P68431 FBLIM1 Homo sapiens Q8WUP2 25416956
Intra
H3C1 P68431 FBLIM1 Homo sapiens Q8WUP2 25416956
Intra
H3C1 P68431 TP53BP1 Homo sapiens Q12888 16415788
Intra
H3C1 P68431 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
H3C1 P68431 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
H3C1 P68431 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
H3C1 P68431 PKM Homo sapiens P14618-1 24606918
Intra
H3C1 P68431 HTT Homo sapiens P42858 23275563
Intra
H3C1 P68431 HTT Homo sapiens P42858 23275563
Intra
H3C1 P68431 WDR5 Homo sapiens P61964
ITC
16946699
Intra
H3C1 P68431 KMT2A Homo sapiens Q03164
ITC
20541251
Intra
H3C1 P68431 KMT2A Homo sapiens Q03164
NMR
20541251
Intra
H3C1 P68431 KMT2A Homo sapiens Q03164 20541251
Intra
H3C1 P68431 A2M Homo sapiens P01023 32814053
Intra
H3C1 P68431 A2M Homo sapiens P01023 32814053
Intra
H3C1 P68431 A2M Homo sapiens P01023 32814053
Intra
H3C1 P68431 NASP Homo sapiens P49321-2 19498464
Intra
H3C1 P68431 NASP Homo sapiens P49321-2 25416956
Intra
H3C1 P68431 NASP Homo sapiens P49321-2 25416956
Intra
H3C1 P68431 TTR Homo sapiens P02766 32814053
Intra
H3C1 P68431 TTR Homo sapiens P02766 32814053
Intra
H3C1 P68431 TTR Homo sapiens P02766 32814053
Intra
H3C1 P68431 NASP Homo sapiens P49321 29568061
Intra
H3C1 P68431 NASP Homo sapiens P49321 29568061
Intra
H3C1 P68431 NASP Homo sapiens P49321
TAP
20080577
Intra
H3C1 P68431 NASP Homo sapiens P49321
TAP
19410544
Intra
H3C1 P68431 NASP Homo sapiens P49321 25281560
Intra
H3C1 P68431 WFS1 Homo sapiens O76024 32814053
Intra
H3C1 P68431 WFS1 Homo sapiens O76024 32814053
Intra
H3C1 P68431 WFS1 Homo sapiens O76024 32814053
Intra
H3C1 P68431 SGF29 Homo sapiens Q96ES7 21685874
Intra
H3C1 P68431 SGF29 Homo sapiens Q96ES7
FPS
21685874
Intra
H3C1 P68431 SGF29 Homo sapiens Q96ES7
ITC
21685874
Intra
H3C1 P68431 CBX1 Homo sapiens P83916 29568061
Intra
H3C1 P68431 CBX1 Homo sapiens P83916 16415788
Intra
H3C1 P68431 CBX1 Homo sapiens P83916
SPR
16415788
Intra
H3C1 P68431 CBX5 Homo sapiens P45973 25281560
Intra
H3C1 P68431 CBX5 Homo sapiens P45973 20871592
Intra
H3C1 P68431 CBX5 Homo sapiens P45973 19498464
Intra
H3C1 P68431 CBX5 Homo sapiens P45973 28514442
Cross
H3C1 P68431 IPL1 Saccharomyces cerevisiae P38991 10949293
Intra
H3C1 P68431 KDM4A Homo sapiens O75164 16415788
Intra
H3C1 P68431 KDM4A Homo sapiens O75164
IF
16603238
Intra
H3C1 P68431 KDM4A Homo sapiens O75164
SPR
16415788
Intra
H3C1 P68431 PEX1 Homo sapiens O43933 32814053
Intra
H3C1 P68431 PEX1 Homo sapiens O43933 32814053
Intra
H3C1 P68431 PEX1 Homo sapiens O43933 32814053
Cross
H3C1 P68431 rhi Drosophila melanogaster Q7JXA8 25613572
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant H3C1 Proteins

Cat. No. Product Name Accession Purity
HY-P72332 Histone H3 Protein, Human P68431 (A2-A136) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72335 Histone H3 Protein, Human (98a.a, His) P68431 (P39-A136) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72798 Histone H3 Protein, Human (His) P68431 (A2-A136) ≥ 90%, as determined by reducing SDS-PAGE.

H3C1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80166 Histone H3 Antibody (YA368) WB, ICC/IF, IHC-P, IP, ChIP Human, Mouse, Rat
HY-P80167 Histone H3 (acetyl K14) Antibody (YA375) WB, ICC/IF, IHC-P, IP, ChIP Human, Mouse, Rat
HY-P80168 Histone H3 (acetyl K18) Antibody (YA736) WB, IHC-P Human, Rat
HY-P80169 Histone H3 (acetyl K27) Antibody (YA735) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat
HY-P80170 Histone H3 (acetyl K56) Antibody (YA374) WB, ICC/IF, IHC-P, ChIP Human, Mouse
HY-P80171 Histone H3 (di methyl K9) Antibody (YA373) WB, ICC/IF, IHC-P Human, Mouse, Rat
HY-P80172 Histone H3 (mono methyl K18) Antibody (YA372) WB, ICC/IF, IHC-P Human, Mouse
HY-P80173 Histone H3 (mono methyl K36)Antibody (YA371) WB, ICC/IF Human, Mouse
HY-P80174 Histone H3 (mono methyl R2)Antibody (YA370) WB, ICC/IF Human, Mouse
HY-P80175 Histone H3 (mono+di+tri methyl K79) Antibody (YA369) WB, IHC-P Human, Mouse, Rat
HY-P80176 Histone H3 (tri methyl K9) Antibody (YA734) WB, IHC-P, ICC/IF, IF-Tissue Human, Mouse, Rat
HY-P80529 Acetyl-Histone H3 (Lys14) Antibody (YA643) WB, ICC/IF, IP Human, Rat
HY-P80529A Acetyl-Histone H3 (Lys14) Antibody (YA643)(PBS only) WB, ICC/IF, IP Human, Rat
HY-P80530 Acetyl-Histone H3 (Lys27) Antibody (YA642) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P80530A Acetyl-Histone H3 (Lys27) Antibody (YA642)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P80531 Acetyl-Histone H3 (Lys4) Antibody (YA641) WB, ICC/IF Human, Mouse
HY-P80531A Acetyl-Histone H3 (Lys4) Antibody (YA641)(PBS only) WB, ICC/IF Human, Mouse
HY-P80643 DiMethyl-Histone H3 Antibody (YA783) WB, ICC/IF, IP Human, Mouse, Rat
HY-P80643A DiMethyl-Histone H3 Antibody (YA783)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat
HY-P80922 TriMethyl-Histone H3 (Lys27) Antibody (YA030) WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P80922A TriMethyl-Histone H3 (Lys27) Antibody (YA030)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP, ChIP Human, Rat
HY-P810556 TriMethyl-Histone H3 (Lys27) Antibody (YA9825) WB, ICC/IF, IHC-P, IF-Tissue, ChIP Human, Mouse, Rat
HY-P810557 MonoMethyl-Histone H3 (Lys9) Antibody (YA9826) WB, ICC/IF, IHC-P, FC, ChIP, IF-Tissue, Dot Blot Human, Mouse, Rat, Monkey
HY-P810558 Acetyl-Histone H3 (Lys18) Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P810559 MonoMethyl-Histone H3 (Lys4) Antibody WB, ICC/IF, IHC-P, FC, Dot Blot Human, Mouse, Rat
HY-P810560 DiMethyl-Histone H3 (Lys4) Antibody WB, ICC/IF, IHC-P, FC, Dot Blot Human, Mouse, Rat
HY-P810561 Acetyl-Histone H3 (Lys9) Antibody (YA9827) WB, ICC/IF, IHC-P, IF-Tissue, FC, ChIP, Dot Blot, IP Human, Mouse, Rat
HY-P810562 Mono+Di+TriMethyl-Histone H3 (Lys36) Antibody (YA9828) WB, IHC-P, ICC/IF, FC, ChIP Human, Mouse, Rat
HY-P810563 Phospho-Histone H3 (Ser28) Antibody (YA9829) WB, ICC/IF, IHC-P, FC, ChIP Human, Mouse, Rat
HY-P810564 Acetyl-Histone H3 (Lys4) Antibody (YA9830) WB, ICC/IF, ChIP, Dot Blot Human, Mouse, Rat
HY-P810565 DiMethyl-Histone H3 (Lys27) Antibody (YA9831) WB, ICC/IF, ChIP Human, Mouse, Rat
HY-P810566 Acetyl-Histone H3 (Lys23) Antibody (YA9832) WB, ICC/IF Human, Mouse
HY-P810567 MonoMethyl-Histone H3 (Lys4) Antibody (YA9833) WB, ICC/IF, ChIP, Dot Blot Human, Mouse, Rat
HY-P810568 Acetyl-Histone H3 (Lys36) Antibody (YA9834) WB, IHC-P, ICC/IF, ChIP Human, Mouse, Rat
HY-P810569 Phospho-Histone H3 (Ser10) Antibody (YA9835) WB, ICC/IF, IHC-P, IP, FC, ChIP Human, Mouse, Rat
HY-P810570 DiMethyl-Histone H3 (Lys4) Antibody (YA9836) WB, ICC/IF, ChIP, Dot Blot, IHC-P Human, Mouse, Rat, Monkey
HY-P810571 MonoMethyl-Histone H3 (Lys14) Antibody (YA9837) WB, ICC/IF, ChIP, Dot Blot Human, Mouse, Rat, Monkey
HY-P810572 Acetyl-Histone H3 (Lys27) Antibody WB, IHC-P, ICC/IF, ChIP Human, Mouse, Rat
HY-P810573 Mono+Di+TriMethyl-Histone H3 (Lys4) Antibody (YA9838) WB, IHC-P, ICC/IF, FC, ChIP Human, Mouse, Rat
HY-P810574 MonoMethyl-Histone H3 (Lys79) Antibody (YA9839) WB, ICC/IF, IHC-P, FC, ChIP Human, Mouse, Rat, Monkey
HY-P810575 TriMethyl-Histone H3 (Lys36) Antibody (YA9840) WB, IHC-P, ICC/IF, IP, Dot Blot, ChIP Human, Mouse, Rat, Monkey
HY-P85644 Histone H3 Antibody(HRP) (YA5336) WB Zebrafish
HY-P85652 Histone H3 Antibody (YA5344) WB, ICC/IF, ELISA Human, Mouse, Rat
HY-P85670 Histone H3 (Di Methyl Lys79) Antibody (YA5362) WB Human, Mouse, Rat
HY-P85671 Histone H3 (Tri Methyl Lys36) Antibody (YA5363) WB, IP Human, Mouse, Rat
HY-P86071 Histone H3 (Tri Methyl Lys36) Antibody (YA5763) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86113 Histone H3 (Di Methyl Lys4) Antibody (YA5805) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat
HY-P86144 Histone H3 (Acetyl Lys36) Antibody (YA5836) WB, IHC-P, ICC/IF, IP, ChIP, ELISA Human, Mouse, Rat
HY-P86148 Histone H3 (Di Methyl Lys9) Antibody (YA5840) WB, IHC-P, ICC/IF, IP, ChIP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Glioma Susceptibility 1
  • Astrocytoma

  • GLM1

  • Glioma, Susceptibility To, Somatic

  • Glioblastoma, Somatic

  • Glioma

  • Glioblastoma Multiforme

  • Oligodendroglioma

  • Glioma Somatic

  • Astrocytic Tumor

  • GLM

  • Familial Glioma Of Brain

  • Gbm

  • Glioma 1

  • Glioma, Susceptibility, Type 1

  • Cerebral Astrocytoma

  • Glioblastoma

  • Well Differentiated Oligodendroglioma

Plasma Cell Neoplasm
  • Plasma Cell Dyscrasia

  • Paraproteinemias

  • Plasma Cell Tumour

  • Plasmacytic Tumor

  • Multiple Myeloma

  • Plasmacytoma

  • Plasma Cell Tumours

  • Plasma Cells Dyscrasia

Myeloma, Multiple
  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]

Histone Mutated Tumor
  • Histone Mutated Tumour

Adult Infiltrating Astrocytic Neoplasm
  • Adult Infiltrating Astrocytoma

  • Adult Infiltrating Astrocytic Tumor

Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted
Diffuse Midline Glioma, H3 K27m-Mutant
  • Diffuse Intrinsic Pontine Glioma

  • Dipg

  • Infiltrative Brainstem Glioma

Brain Stem Cancer
  • Brain Stem Neoplasms

  • Malignant Neoplasm Of Brain Stem

  • Malignant Neoplasm Of Brainstem

  • Neoplasm Of Adult Brain Stem

  • Neoplasm Of Brain Stem

  • Primary Brain Stem Neoplasm

  • Primary Brain Stem Tumor

  • Brain Stem Neoplasm

  • Brain Stem--Cancer

  • Brain Stem Neoplasms, Primary

Hutchinson-Gilford Progeria Syndrome
  • Progeria

  • HGPS

  • Hutchinson-Gilford Syndrome

  • Hutchinson-Gilford Progeria

  • Hutchinson Gilford Syndrome

  • Hutchinson Gilford Progeria Syndrome

  • Hutchinson-Gilford Disease

  • Progeria Of Childhood

  • Hutchinson-Gilford-Progeria Syndrome

Childhood Brain Stem Glioma
  • Pediatric Glioma Of The Brainstem

Brain Stem Glioma
  • Brainstem Glioma

  • Brainstem Neuroglial Tumor

  • Glioma Of Brainstem

Diffuse Large B-Cell Lymphoma
  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma

Posterior Fossa Ependymoma
Glioblastoma
  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma

Adult Astrocytic Tumour
  • Adult Astrocytoma

  • Adult Astrocytic Tumors

Pilomyxoid Astrocytoma
Low Grade Glioma
  • Benign Glioma

Pilocytic Astrocytoma
  • Juvenile Pilocytic Astrocytoma

  • Grade I Astrocytic Tumor

  • Piloid Astrocytoma

Central Nervous System Benign Neoplasm
  • Benign Neoplasm Of The Central Nervous System

Medulloblastoma
  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus H3C1 RGD RGD:1598076
Mus musculus H3C1 MGD MGI:2668828