H3C1 - H3 clustered histone 1 Gene

Homo sapiens

Also known as H3/A; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FA; H3C10; H3C11; H3C12; HIST1H3A

Gene ID: 8350 | Gene type: protein coding

About H3C1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,020,451-26,020,958 (from NCBI)

This gene has 1 transcript (splice variant), 96 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3C1 Products(1)

mRNA	Protein	Name
NM_003529.3	NP_003520.1	histone H3.1

H3C1 Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names

Protein Names

histone H3.1

H3 histone family, member A

Recombinant H3C1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72332	Histone H3 Protein, Human	P68431 (A2-A136)	≥95%
HY-P72335	Histone H3 Protein, Human (98a.a, His)	P68431 (P39-A136)	≥95%
HY-P72798	Histone H3 Protein, Human (His)	P68431 (A2-A136)	≥95%
HY-P72332A	Histone H3 Protein, Human (N-His)	P68431 (A2-A136)	≥95%

Related Diseases

Diseases

Alias

Glioma Susceptibility 1

Astrocytoma	GLM1
Glioma, Susceptibility To, Somatic	Glioblastoma, Somatic
Glioma	Glioblastoma Multiforme
Oligodendroglioma	Glioma Somatic
Astrocytic Tumor	GLM
Familial Glioma Of Brain	Gbm
Glioma 1	Glioma, Susceptibility, Type 1
Cerebral Astrocytoma	Glioblastoma
Well Differentiated Oligodendroglioma

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Histone Mutated Tumor

Histone Mutated Tumour

Adult Infiltrating Astrocytic Neoplasm

Adult Infiltrating Astrocytoma

Adult Infiltrating Astrocytic Tumor

Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted

Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma	Dipg
Infiltrative Brainstem Glioma

Brain Stem Cancer

Brain Stem Neoplasms	Malignant Neoplasm Of Brain Stem
Malignant Neoplasm Of Brainstem	Neoplasm Of Adult Brain Stem
Neoplasm Of Brain Stem	Primary Brain Stem Neoplasm
Primary Brain Stem Tumor	Brain Stem Neoplasm
Brain Stem--Cancer	Brain Stem Neoplasms, Primary

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Brain Stem Glioma

Brainstem Glioma	Brainstem Neuroglial Tumor
Glioma Of Brainstem

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Posterior Fossa Ependymoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors

Pilomyxoid Astrocytoma

Low Grade Glioma

Benign Glioma

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma	Grade I Astrocytic Tumor
Piloid Astrocytoma

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05966	H3C1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	H3C1	RGD	RGD:1598076
Mus musculus	H3C1	MGD	MGI:2668828