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MPHOSPH8 - M-phase phosphoprotein 8 Gene

Also Known as TWA3; mpp8; HSMPP8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54737

About MPHOSPH8

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,633,659-19,673,441 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 20.0), spleen (RPKM 15.8) and 25 other tissues.

Summary

Enables chromatin binding activity and methylated histone binding activity. Involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; regulation of DNA methylation; and regulation of gene expression. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

MPHOSPH8 Products (1)

mRNA	Protein	Name
NM_017520.4	NP_059990.2	M-phase phosphoprotein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	29211708	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	20871592	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	20871592	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20871592	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	20871592	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	26022416	GOA
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IMP IMP: Inferred from mutant phenotype	29211708	GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IDA IDA: Inferred from direct assay	28581500	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8885239	GOA
located in heterochromatin	IDA IDA: Inferred from direct assay	20871592	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	20871592	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8885239	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPHOSPH8 Protein Structure

Chromo

Ank_2

Ank

0
200
400
600
800
860 a.a.

Protein Preferred Names	Protein Names
M-phase phosphoprotein 8	M-phase phosphoprotein, mpp

MPHOSPH8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MPHOSPH8	Q99549	EHMT1	Homo sapiens	Q9H9B1	Anti Tag CoIP	26496610
Intra	MPHOSPH8	Q99549	EHMT1	Homo sapiens	Q9H9B1	Anti Bait CoIP	20871592
Intra	MPHOSPH8	Q99549	SETDB1	Homo sapiens	Q15047	Anti Bait CoIP	20871592
Intra	MPHOSPH8	Q99549	H3C1	Homo sapiens	P68431	Protein Array	20871592

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyperoxaluria, Primary, Type I	Primary Hyperoxaluria Type 1 HP1 Glycolic Aciduria Alanine-Glyoxylate Aminotransferase Deficiency Hepatic Agt Deficiency Oxalosis I Primary Hyperoxaluria, Type I Serine:Pyruvate Aminotransferase Deficiency Hyperoxaluria, Primary, Type 1 Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency Serine Pyruvate Aminotransferase Deficiency Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Oxalosis 1 Hyperoxaluria Primary 1 Hyperoxaluria Primary Type I Ph1 Primary Hyperoxaluria Type I Oxalosis Type 1 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08612	MPHOSPH8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MPHOSPH8	VGNC	VGNC:31575
Mus musculus	MPHOSPH8	MGD	MGI:1922589
Rattus norvegicus	MPHOSPH8	RGD	RGD:1305133
Macaca mulatta	MPHOSPH8	VGNC	VGNC:74864
Felis catus	MPHOSPH8	VGNC	VGNC:63571
Others	MPHOSPH8	NCBI