CDYL - chromodomain Y like Gene

Also Known as CDYL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9425

About CDYL

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:4,706,138-4,955,544 (from NCBI)

This gene has 9 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in placenta (RPKM 8.5), endometrium (RPKM 8.1) and 25 other tissues.

Summary

Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

CDYL Products (6)

mRNA	Protein	Name
NM_001143970.2	NP_001137442.1	chromodomain Y-like protein isoform d
NM_001143971.2	NP_001137443.1	chromodomain Y-like protein isoform d
NM_001368125.1	NP_001355054.1	chromodomain Y-like protein isoform e
NM_001368126.1	NP_001355055.1	chromodomain Y-like protein isoform f
NM_001368127.1	NP_001355056.1	chromodomain Y-like protein isoform g
NM_004824.4	NP_004815.3	chromodomain Y-like protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables crotonyl-CoA hydratase activity	IDA IDA: Inferred from direct assay	28803779	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
NOT enables methylated histone binding	IDA IDA: Inferred from direct assay	18450745	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	22009739	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16415788	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	19061646	GOA
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	19061646	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of peptidyl-lysine crotonylation	IDA IDA: Inferred from direct assay	28803779	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18450745	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDYL Protein Structure

Chromo

ECH_1

0
100
200
300
400
500
598 a.a.

Protein Preferred Names	Protein Names
chromodomain Y-like protein	CDY-like, autosomal

CDYL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDYL	Q9Y232	FXR1	Homo sapiens	P51114	Y2H Pooling	21653829
Intra	CDYL	Q9Y232	FXR1	Homo sapiens	P51114	Anti Tag CoIP	21653829
Intra	CDYL	Q9Y232	H3C1	Homo sapiens	P68431	Protein Array	16415788
Intra	CDYL	Q9Y232	H3C1	Homo sapiens	P68431	Far-WB	16415788

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 6pter-P24 Deletion Syndrome	6p Subtelomeric Deletion Syndrome 6p25 Microdeletion Syndrome Distal Monosomy 6p Distal Deletion 6p Monosomy 6p25

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W105310A	Croconic acid disodium		99.98%	Unkown
HY-161904	CDYL-IN-1	Inhibitor	99.80%	Unkown
HY-RS02433	CDYL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02434	CDYL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20879	Cdyl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27396	Cdyl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDYL	RGD	RGD:1549745
Felis catus	CDYL	VGNC	VGNC:102399
Macaca mulatta	CDYL	VGNC	VGNC:70998
Mus musculus	CDYL	MGD	MGI:1339956
Bos taurus	CDYL	VGNC	VGNC:55900
Canis familiaris	CDYL	VGNC	VGNC:59137
Others	CDYL	NCBI