NASP - nuclear autoantigenic sperm protein Gene

Also Known as HMDRA1; FLB7527; PRO1999

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4678

About NASP

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,584,041-45,618,893 (from NCBI)

This gene has 25 transcripts (splice variants) and 273 orthologues. Ubiquitous expression in testis (RPKM 44.0), bone marrow (RPKM 30.2) and 24 other tissues.

Summary

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

NASP Products (3)

mRNA Protein Name
NM_001195193.2 NP_001182122.1 nuclear autoantigenic sperm protein isoform 4
NM_002482.4 NP_002473.2 nuclear autoantigenic sperm protein isoform 2
NM_152298.4 NP_689511.2 nuclear autoantigenic sperm protein isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone binding IDA
IDA: Inferred from direct assay
27618665 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
25615412 GOA
Biological Process GO Annotation Evidence References Source
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
14718166 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NASP Protein Structure

SHNi-TPR

SHNi-TPR: SHNi-TPR (542 - 579)

TPR_1

TPR_1: Tetratricopeptide repeat (584 - 614)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

nuclear autoantigenic sperm protein

  • NASP histone chaperone

NASP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NASP P49321 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
NASP P49321 H3C1 Homo sapiens P68431
Anti Tag CoIP
33961781
Intra
NASP P49321 H3C1 Homo sapiens P68431
TAP
24981860
Intra
NASP P49321 H3C1 Homo sapiens P68431
Y2H Pooling
16189514
Intra
NASP P49321 H3C1 Homo sapiens P68431
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Factitious Disorder

  • Munchausen Syndrome

  • Factitious Disorders

  • Münchausen Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09038 NASP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20303 Nasp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26811 Nasp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NASP VGNC VGNC:43626
Rattus norvegicus NASP RGD RGD:1359609
Felis catus NASP VGNC VGNC:68417
Mus musculus NASP MGD MGI:1355328
Bos taurus NASP VGNC VGNC:31887
Macaca mulatta NASP VGNC VGNC:82193
Others NASP NCBI