2. Gene
  3. NASP - nuclear autoantigenic sperm protein Gene

NASP - nuclear autoantigenic sperm protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HMDRA1; FLB7527; PRO1999

Gene ID: 4678 | Gene type: protein coding

About NASP

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,584,041-45,618,893 (from NCBI)

This gene has 25 transcripts (splice variants) and 273 orthologues. Ubiquitous expression in testis (RPKM 44.0), bone marrow (RPKM 30.2) and 24 other tissues.

Summary

This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

NASP Products(3)

mRNA Protein Name
NM_001195193.2 NP_001182122.1 nuclear autoantigenic sperm protein isoform 4
NM_002482.4 NP_002473.2 nuclear autoantigenic sperm protein isoform 2
NM_152298.4 NP_689511.2 nuclear autoantigenic sperm protein isoform 3

NASP Protein Structure

SHNi-TPR

SHNi-TPR: SHNi-TPR (542 - 579)

TPR_1

TPR_1: Tetratricopeptide repeat (584 - 614)

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  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

nuclear autoantigenic sperm protein

NASP histone chaperone

Related Diseases

Diseases Alias
Factitious Disorder

Munchausen Syndrome

Factitious Disorders

Münchausen Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09038 NASP Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NASP VGNC VGNC:43626
Rattus norvegicus NASP RGD RGD:1359609
Felis catus NASP VGNC VGNC:68417
Mus musculus NASP MGD MGI:1355328
Bos taurus NASP VGNC VGNC:31887
Macaca mulatta NASP VGNC VGNC:82193