KDM4A - lysine demethylase 4A Gene

Also Known as JMJD2; JHDM3A; JMJD2A; TDRD14A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9682

About KDM4A

Cytogenetic location: 1p34.2-p34.1 Genomic coordinates (GRCh38): 1:43,650,149-43,705,518 (from NCBI)

This gene has 5 transcripts (splice variants), 137 orthologues and 10 paralogues. Ubiquitous expression in duodenum (RPKM 11.5), thyroid (RPKM 10.1) and 25 other tissues.

Summary

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

KDM4A Products (1)

mRNA	Protein	Name
NM_014663.3	NP_055478.2	lysine-specific demethylase 4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H3K36 demethylase activity	IDA IDA: Inferred from direct assay	16024779	GOA
enables histone H3K9me2/H3K9me3 demethylase activity	IMP IMP: Inferred from mutant phenotype	21914792	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	22373579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16415788	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22373579	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	27214403	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16024779	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25660547	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25660547	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16024779	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	21914792	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM4A Protein Structure

JmjN

JmjC

PHD_2

zf-HC5HC2H_2

0
200
400
600
800
1000
1064 a.a.

Protein Preferred Names	Protein Names
lysine-specific demethylase 4A	[histone H3]-trimethyl-L-lysine(36) demethylase 4A

KDM4A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KDM4A	O75164	H4C16	Homo sapiens	P62805	Pull Down	22373579
Intra	KDM4A	O75164	H4C16	Homo sapiens	P62805	Far-WB	16415788
Intra	KDM4A	O75164	H4C16	Homo sapiens	P62805	Pull Down	16415788
Intra	KDM4A	O75164	H4C16	Homo sapiens	P62805	SPR	16415788
Intra	KDM4A	O75164	H3-4	Homo sapiens	Q16695	SPR	17567753
Intra	KDM4A	O75164	H3-4	Homo sapiens	Q16695	Demethylase Assay	17567753
Intra	KDM4A	O75164	H3-4	Homo sapiens	Q16695	X-Ray Diffraction	17567753
Intra	KDM4A	O75164	H3C1	Homo sapiens	P68431	Far-WB	16415788
Intra	KDM4A	O75164	H3C1	Homo sapiens	P68431	Pull Down	16415788
Intra	KDM4A	O75164	H3C1	Homo sapiens	P68431	SPR	16415788

Cross: Cross-species interaction Intra: Intraspecies interaction

KDM4A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83586	KDM4A/JHDM3A/JMJD2A Antibody (YA3331)	WB, IP	Human
HY-P83586A	KDM4A/JHDM3A/JMJD2A Antibody (YA3331)(PBS only)	WB, IP	Human
HY-P85236	KDM4A/JHDM3A/JMJD2A Antibody (YA4928)	WB; IHC-P; IHC-F; IP; IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-104048	QC6352	Inhibitor	99.13%	Unkown
HY-100760	Toxoflavin	Inhibitor	99.88%	Unkown
HY-148807	Zavondemstat		99.29%	Unkown
HY-107573	KDM2/7-IN-1	Inhibitor	99.9%	Unkown
HY-110154	NSC636819		98.90%	Unkown
HY-RS07213	KDM4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-128343	KDM4-IN-2	Inhibitor	98.29%	Unkown
HY-120766	NCDM-32B	Inhibitor	97.0%	Unkown
HY-148807A	Zavondemstat L-lysine		/	Unkown
HY-173135	PROTAC KDM4 degrader-1		/	Unkown
HY-100760S	Toxoflavin-13C4	Inhibitor	/	Unkown
HY-148807C	Zavondemstat sodium		/	Unkown
HY-150619	KDM4-IN-4	Inhibitor	/	Unkown
HY-183618	DW-229	Degrader	/	Unkown
HY-RS17467	Kdm4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23925	Kdm4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KDM4A	VGNC	VGNC:30527
Rattus norvegicus	KDM4A	RGD	RGD:1306378
Macaca mulatta	KDM4A	VGNC	VGNC:99987
Felis catus	KDM4A	VGNC	VGNC:80248
Mus musculus	KDM4A	MGD	MGI:2446210
Canis familiaris	KDM4A	VGNC	VGNC:42324
Others	KDM4A	NCBI