H3-4 - H3.4 histone, cluster member Gene

Homo sapiens

Also known as H3t; H3.4; H3/g; H3FT; H3C16; HIST3H3

Gene ID: 8290 | Gene type: protein coding

About H3-4

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,424,845-228,425,360 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 115 orthologues, 20 paralogues and is associated with 1 phenotype.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3-4 Products(1)

mRNA	Protein	Name
NM_003493.3	NP_003484.1	histone H3.1t

H3-4 Protein Structure

Histone

0
100
136 a.a.

Protein Preferred Names

Protein Names

histone H3.1t

H3 clustered histone 16

Related Diseases

Diseases

Alias

Colon Leiomyoma

Colonic Leiomyoma

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05963	H3-4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	H3-4	RGD	RGD:1583877
Macaca mulatta	H3-4	VGNC	VGNC:109730
Mus musculus	H3-4	MGD	MGI:3651326